MUC4 Antibody (3C7.D8.E11.F5)

• Reactivity: Hu
• Applications: WB, ELISA, IHC
• Clone: 3C7.D8.E11.F5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

MUC4 Antibody (3C7.D8.E11.F5) Summary

• Immunogen: Peptide corresponding to an internal portion of human Mucin-4.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: MUC4
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Western Blot
• Application Notes: This antibody has been tested by in ELISA, IHC, and Western Blot. Antibodies shows no cross reactivity to non-mucilated proteins. Positive control used in WB were HPAC, HPAF-II, and Capan-2 cell lines.

Reactivity Notes

BLAST analysis was used to suggest cross reactivity with MUC4 from human based on 100% sequence homology with the immunogen. Reactivity with MUC4 from other sources is not known.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Preservative: 0.01% Sodium Azide
• Purity: Protein A purified

Alternate Names for MUC4 Antibody (3C7.D8.E11.F5)

• Ascites sialoglycoprotein
• ASGP
• HSA276359
• MUC4
• MUC-4
• mucin 4, cell surface associated
• mucin 4, tracheobronchial
• mucin-4
• Pancreatic adenocarcinoma mucin
• Testis mucin
• Tracheobronchial mucin

Background

MUC4 is a constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, and is a highly glycosylated proteins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. MUC4 antibody studies have shown that MUC4 encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of MUC4 have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. MUC4 is expressed in a wide variety of carcinomas making MUC4 antibodies a key cancer research tool.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MUC4