M3II-21 reacts with an internal epitope of MRP3, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP1. M3II-21 was raised against a bacterial fusion protein of MRP3, containing amino acids 830-949 of the protein. M3II-21 does not cross-react with the human MDR1, MRP1, MRP2 or MRP5 gene products
Tissue culture supernatant
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M3II-21 has potential value for detection of MRP3-mediated drug-resistance in human tumor samples. Immunocytochemistry: use 1:20-1:50 dil. on acetone or formaldehyde fixed cytospin preparations. For immunohistochemistry: use 1:20 on acetone fixed frozen sections. Western Blot: use 1:20-1:50 dil, and anti-Mouse HRP. Flow Cytometry: optimal conditions still to be defined. Use in Simple Western reported in scientific literature (PMID: 29890265).
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