Mrc2 Antibody (SR1302) - BSA Free

Western Blot: Mrc2 Antibody (SR1302) [NBP3-22115] - Western blot analysis using NBP3-22115 in Saos2 cell lysate.

• Reactivity: Hu
• Applications: WB
• Clone: SR1302
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Mrc2 Antibody (SR1302) - BSA Free Summary

• Description: Novus Biologicals Rabbit Mrc2 Antibody (SR1302) - BSA Free (NBP3-22115) is a recombinant monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human Mrc2 (Uniprot #: Q9UBG0)
• Specificity: Detects endogenous levels of total Mrc2
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MRC2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:2000
• Theoretical MW: 190 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Mrc2 Antibody (SR1302) - BSA Free

• CD280 antigen
• CD280
• CD280C-type mannose receptor 2
• CLEC13E
• CLEC13EUPAR-associated protein
• Endo180
• ENDO180C-type lectin domain family 13 member E
• Endocytic receptor 180
• KIAA0709FLJ35911
• Macrophage mannose receptor 2
• mannose receptor, C type 2
• Mrc2
• uPARAP
• UPARAPendocytic receptor (macrophage mannose receptor family)
• urokinase plasminogen activator receptor-associated protein
• Urokinase receptor-associated protein
• Urokinase-type plasminogen activator receptor-associated protein

Background

MRC2, also known as C-type mannose receptor 2, is a 1,479 amino acid protein that is 167 kDa, plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands, may be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface, and may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. Disease research is currently being studied with relations to MRC2 and breast cancer, aortic aneurysm, prostate cancer, progression of osteoarthritis, prostatitis,s, schizophrenia, tuberculosis, immunodeficiency, and hepatitis. Interactions with this protein have shown to involve NDEL1, IL10, TGFB1, TGFB2, TGFB3, and UBC in antigen processing-cross presentation, cross-presentation of soluble exogenous antigens (endosomes), adaptive immune system, class I MHC mediated antigen processing & presentation, immune system, phagosome, and tuberculosis pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MRC2