Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit



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Reactivity MuSpecies Glossary
Applications ELISA

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Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit Summary

The Quantikine Mouse TRANCE Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TRANCE in cell culture supernates and serum. It contains NS0-expressed recombinant mouse TRANCE and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse TRANCE accurately. Results obtained using natural mouse TRANCE showed dose respons...e curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TRANCE.
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Free natural and recombinant mouse TRANCE
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
Interference observed with 1 or more available related molecules.
Read Publications using MTR00.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11


TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for TRANCE/TNFSF11/RANK L (MTR00)(51)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

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Showing Publications 1 - 10 of 51. Show All 51 Publications.
Publications using MTR00 Applications Species
T Velletri, Y Huang, Y Wang, Q Li, M Hu, N Xie, Q Yang, X Chen, Q Chen, P Shou, Y Gan, E Candi, AP Margherita, M Agostini, H Yang, G Melino, Y Shi, Y Wang Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin Cell Death Differ., 2020;0(0):. 2020 [PMID: 32694652] (Mouse) Mouse
K Sahbani, CP Cardozo, WA Bauman, HA Tawfeek Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and beta-arrestin recruitment than teriparatide Physiol Rep, 2019;7(19):e14225. 2019 [PMID: 31565870] (Mouse) Mouse
T Heckt, LJ Brylka, M Neven, M Amling, T Schinke Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase PLoS ONE, 2019;14(7):e0219734. 2019 [PMID: 31314788] (Mouse) Mouse
X Gao, A Lu, Y Tang, J Schneppend, AB Liebowitz, AC Scibetta, ER Morris, H Cheng, C Huard, S Amra, B Wang, MA Hall, WR Lowe, J Huard Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration Stem Cell Res Ther, 2018;9(1):316. 2018 [PMID: 30463597] (Mouse) Mouse
Y Ikebuchi, S Aoki, M Honma, M Hayashi, Y Sugamori, M Khan, Y Kariya, G Kato, Y Tabata, JM Penninger, N Udagawa, K Aoki, H Suzuki Coupling of bone resorption and formation by RANKL reverse signalling Nature, 2018;0(0):. 2018 [PMID: 30185903] (Mouse) Mouse
SM Zimmerman, ME Heard-Lips, M Dimori, JD Thostenson, EM Mannen, CA O'Brien, R Morello Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim) Bone Rep, 2018;9(0):61-73. 2018 [PMID: 30105276] (Mouse) Mouse
J Xiong, K Cawley, M Piemontese, Y Fujiwara, H Zhao, JJ Goellner, CA O'Brien Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss Nat Commun, 2018;9(1):2909. 2018 [PMID: 30046091] (Mouse) Mouse
LC Cheung, J Tickner, AM Hughes, P Skut, M Howlett, B Foley, J Oommen, JE Wells, B He, S Singh, GA Chua, J Ford, CG Mullighan, RS Kotecha, UR Kees New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment Leukemia, 2018;0(0):. 2018 [PMID: 29740160] (Mouse) Mouse
NJ Lee, IM Clarke, RF Enriquez, V Nagy, J Penninger, PA Baldock, H Herzog Central RANK signalling in NPY neurons alters bone mass in male mice Neuropeptides, 2018;0(0):. 2018 [PMID: 29477253] (Mouse) Mouse
N Yang, B Baban, CM Isales, XM Shi Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss PLoS ONE, 2017;12(8):e0181133. 2017 [PMID: 28771604] (Mouse) Mouse
Show All 51 Publications.

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Product General Protocols

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FAQs for TRANCE/TNFSF11/RANK L (MTR00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

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The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...  Read full blog post.

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Gene Symbol Tnfsf11