Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse TRANCE Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TRANCE in cell culture supernates and serum. It contains NS0-expressed recombinant mouse TRANCE and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse TRANCE accurately. Results obtained using natural mouse TRANCE showed dose respons...e curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TRANCE.
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• Specificity: Free natural and recombinant mouse TRANCE
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnfsf11

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit

• CD254 antigen
• CD254
• ODF
• OPGL
• OPGLOPTB2
• Osteoclast differentiation factor
• Osteoprotegerin ligand
• RANK L
• RANKL
• RANKLreceptor activator of nuclear factor kappa B ligand
• Receptor activator of nuclear factor kappa-B ligand
• sOdf
• TNF-related activation-induced cytokine
• TNFSF11
• TRANCE
• TRANCEODFhRANKL2
• tumor necrosis factor (ligand) superfamily, member 11
• tumor necrosis factor ligand superfamily member 11

Background

TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TRANCE/TNFSF11/RANK L (MTR00)(72)

Publications using MTR00

• Tanaka, Y;Takahashi, Y;Shindo, Y;Pitstick, LB;Teitelbaum, SL;Zou, W;Wang, X;Woods, J;Wikenheiser-Brokamp, KA;McCormack, FX; Hydroxyapatite microspheres induce durable pleurodesis and are rapidly cleared by pleural osteoclasts JCI insight 2025-08-21 [PMID: 40857249] (Mouse)
• Fernández-Villabrille, S;Baena-Huerta, F;Suárez-Fernández, L;Nefyodova, E;Calvó, P;González-García, N;Gil-Peña, H;Gómez-Alonso, C;Alonso-Montes, C;Naves-Díaz, M;Maes, C;Carrillo-López, N;Panizo, S; High Dietary Phosphorus Impairs Bone Microarchitecture and Induces Alterations in the LGR4-R-Spondins Axis in Rats with Normal Renal Function Nutrients 2025-06-19 [PMID: 40573160] (Rat)
• Fu, W;Chen, M;Wang, K;Chen, Y;Cui, Y;Xie, Y;Lei, ZN;Hu, W;Sun, G;Huang, G;He, C;Fretz, J;Hettinghouse, A;Liu, R;Cai, X;Zhang, M;Chen, Y;Jiang, N;He, M;Wiznia, DH;Xu, H;Chen, ZS;Chen, L;Tang, K;Zhou, H;Liu, CJ; Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss Cell research 2025-01-01 [PMID: 39743632] (Mouse)
• Uehara, N;Shibusawa, N;Mikami, Y;Kyumoto-Nakamura, Y;Sonoda, S;Kato, H;Yamaza, T;Kukita, T; Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling Archives of biochemistry and biophysics 2023-12-01 [PMID: 37979903] (Mouse)
• Miyagawa, K;Tenshin, H;Mulcrone, PL;Delgado-Calle, J;Subler, MA;Windle, JJ;Chirgwin, JM;Roodman, GD;Kurihara, N; Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to Pagetic lesion formation JCI insight 2023-06-20 [PMID: 37338990] (Mouse)
• X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair International Journal of Molecular Sciences, 2023-01-25;24(3):. 2023-01-25 [PMID: 36768718] (Mouse)
• X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768718] (Mouse)
• C Polan, C Brenner, M Herten, G Hilken, F Grabellus, HL Meyer, M Burggraf, M Dudda, W Jahnen-Dec, C Wedemeyer, MD Kauther Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice Journal of functional biomaterials, 2023-01-04;14(1):. 2023-01-04 [PMID: 36662077] (Mouse)
• Ziru Li, Emily Bowers, Junxiong Zhu, Hui Yu, Julie Hardij, Devika P Bagchi et al. Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits eLife 2022-06-22 [PMID: 35731039] (Mouse)
• JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes Cell Death and Differentiation, 2022-02-15;0(0):. 2022-02-15 [PMID: 35169297] (Mouse)
• JJM Junqueira, JD Lourenço, KR da Silva, V Jorgetti, RP Vieira, AA de Araujo, K De Angelis, AT Correia, LHV Alves, IFLC Tibério, AP Barbosa, FDTQDS Lopes Increased bone resorption by long-term cigarette smoke exposure in animal model Heliyon, 2021-12-10;7(12):e08587. 2021-12-10 [PMID: 34977408] (Mouse)
• W Zhao, P Wiedemann, EM Wölfel, M Neven, S Peters, T Imhof, M Koch, B Busse, M Amling, T Schinke, TA Yorgan Decreased Trabecular Bone Mass in Col22a1-Deficient Mice Cells, 2021-11-04;10(11):. 2021-11-04 [PMID: 34831244] (Mouse)
• N Liao, T Koehne, J Tuckermann, I Triviai, M Amling, JP David, T Schinke, J Luther Osteoblast-specific inactivation of p53 results in locally increased bone formation PLoS ONE, 2021-11-18;16(11):e0249894. 2021-11-18 [PMID: 34793446] (Mouse)
• EJ Lee, W Na, MK Kang, YH Kim, DY Kim, H Oh, SI Kim, SY Oh, S Park, K Park, YH Kang Hydroxycoumarin Scopoletin Inhibits Bone Loss through Enhancing Induction of Bone Turnover Markers in a Mouse Model of Type 2 Diabetes Biomedicines, 2021-06-07;9(6):. 2021-06-07 [PMID: 34200167] (Mouse)
• RS MacLeod, MB Meyer, J Xiong, KM Cawley, Y Liu, M Onal, NA Benkusky, JD Thostenson, JW Pike, CA O'Brien Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo PLoS ONE, 2021-05-10;16(5):e0250974. 2021-05-10 [PMID: 33970941] (Mouse, Transgenic Mouse)
• M Timmen, H Hidding, M Götte, TE Khassawna, D Kronenberg, R Stange The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis Sci Rep, 2020-11-25;10(1):20510. 2020-11-25 [PMID: 33239699] (Mouse)
• KM Cawley, NC Bustamante, AG Guha, RS MacLeod, J Xiong, I Gubrij, Y Liu, R Mulkey, M Palmieri, JD Thostenson, JJ Goellner, CA O'Brien Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption Cell Rep, 2020-09-08;32(10):108052. 2020-09-08 [PMID: 32905775] (Mouse)
• S Kato, N Tanabe, M Nagao, J Sekino, K Tomita, M Sakai, K Abe, N Suzuki, K Ueda Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions J Oral Sci, 2020-08-31;0(0):. 2020-08-31 [PMID: 32863319] (Mouse)
• M Koide, T Yamashita, K Murakami, S Uehara, K Nakamura, M Nakamura, M Matsushita, T Ara, H Yasuda, JM Penninger, N Takahashi, N Udagawa, Y Kobayashi Sclerostin expression in trabecular bone is downregulated by osteoclasts Sci Rep, 2020-08-13;10(1):13751. 2020-08-13 [PMID: 32792620] (Mouse)
• T Velletri, Y Huang, Y Wang, Q Li, M Hu, N Xie, Q Yang, X Chen, Q Chen, P Shou, Y Gan, E Candi, AP Margherita, M Agostini, H Yang, G Melino, Y Shi, Y Wang Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin Cell Death Differ., 2020-07-21;0(0):. 2020-07-21 [PMID: 32694652] (Mouse)
• K Sahbani, CP Cardozo, WA Bauman, HA Tawfeek Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and beta-arrestin recruitment than teriparatide Physiol Rep, 2019-10-01;7(19):e14225. 2019-10-01 [PMID: 31565870] (Mouse)
• T Heckt, LJ Brylka, M Neven, M Amling, T Schinke Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase PLoS ONE, 2019-07-17;14(7):e0219734. 2019-07-17 [PMID: 31314788] (Mouse)
• F Wauquier, A Daneault, H Granel, J Prawitt, V Fabien Sou, J Berger, B Pereira, J Guicheux, GY Rochefort, N Meunier, A Blot, Y Wittrant Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa Nutrients, 2019-05-31;11(6):. 2019-05-31 [PMID: 31159319] (Mouse)
• X Gao, A Lu, Y Tang, J Schneppend, AB Liebowitz, AC Scibetta, ER Morris, H Cheng, C Huard, S Amra, B Wang, MA Hall, WR Lowe, J Huard Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration Stem Cell Res Ther, 2018-11-21;9(1):316. 2018-11-21 [PMID: 30463597] (Mouse)
• Y Ikebuchi, S Aoki, M Honma, M Hayashi, Y Sugamori, M Khan, Y Kariya, G Kato, Y Tabata, JM Penninger, N Udagawa, K Aoki, H Suzuki Coupling of bone resorption and formation by RANKL reverse signalling Nature, 2018-09-05;0(0):. 2018-09-05 [PMID: 30185903] (Mouse)
• SM Zimmerman, ME Heard-Lips, M Dimori, JD Thostenson, EM Mannen, CA O'Brien, R Morello Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim) Bone Rep, 2018-07-02;9(0):61-73. 2018-07-02 [PMID: 30105276] (Mouse)
• J Xiong, K Cawley, M Piemontese, Y Fujiwara, H Zhao, JJ Goellner, CA O'Brien Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss Nat Commun, 2018-07-25;9(1):2909. 2018-07-25 [PMID: 30046091] (Mouse)
• LC Cheung, J Tickner, AM Hughes, P Skut, M Howlett, B Foley, J Oommen, JE Wells, B He, S Singh, GA Chua, J Ford, CG Mullighan, RS Kotecha, UR Kees New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment Leukemia, 2018-05-08;0(0):. 2018-05-08 [PMID: 29740160] (Mouse)
• NJ Lee, IM Clarke, RF Enriquez, V Nagy, J Penninger, PA Baldock, H Herzog Central RANK signalling in NPY neurons alters bone mass in male mice Neuropeptides, 2018-02-15;0(0):. 2018-02-15 [PMID: 29477253] (Mouse)
• N Yang, B Baban, CM Isales, XM Shi Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss PLoS ONE, 2017-08-03;12(8):e0181133. 2017-08-03 [PMID: 28771604] (Mouse)
• OJ Park, J Kim, J Yang, CH Yun, SH Han Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2 J. Bone Miner. Res, 2017-04-27;0(0):. 2017-04-27 [PMID: 28337794] (Mouse)
• HM Davis, R Pacheco-Co, EG Atkinson, LR Brun, AR Gortazar, J Harris, M Hiasa, SA Bolarinwa, T Yoneda, M Ivan, A Bruzzaniti, T Bellido, LI Plotkin Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging Aging Cell, 2017-03-19;0(0):. 2017-03-19 [PMID: 28317237] (Mouse)
• Silicon Nitride: A Synthetic Mineral for Vertebrate Biology Sci Rep, 2016-08-19;6(0):31717. 2016-08-19 [PMID: 27539146] (Human)
• Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem, 2015-06-17;290(33):20147-58. 2015-06-17 [PMID: 26085099] (Mouse)
• Yang Y, Blair H, Shapiro I, Wang B The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway. J Biol Chem, 2015-05-15;290(27):16918-28. 2015-05-15 [PMID: 25979341] (Mouse)
• Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino M, Akira S 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J Biol Chem, 2015-02-17;290(15):9377-86. 2015-02-17 [PMID: 25691576] (Mouse)
• Nollet M, Santucci-Darmanin S, Breuil V, Al-Sahlanee R, Cros C, Topi M, Momier D, Samson M, Pagnotta S, Cailleteau L, Battaglia S, Farlay D, Dacquin R, Barois N, Jurdic P, Boivin G, Heymann D, Lafont F, Lu S, Dempster D, Carle G, Pierrefite-Carle V Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Autophagy, 2014-01-01;10(11):1965-77. 2014-01-01 [PMID: 25484092] (Mouse)
• Onal M, Bishop K, St John H, Danielson A, Riley E, Piemontese M, Xiong J, Goellner J, O'Brien C, Pike J A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res, 2015-05-01;30(5):855-68. 2015-05-01 [PMID: 25431114] (Mouse)
• Baek , Jong Min, Kim , Ju-Young, Cheon , Yoon-Hee, Park , Sun-Hyan, Ahn , Sung-Jun, Yoon , Kwon-Ha, Oh , Jaemin, Lee , Myeung S Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone loss in mice. Molecules, 2014-08-05;19(8):11628-44. 2014-08-05 [PMID: 25100255] (Mouse)
• Teufel S, Grotsch B, Luther J, Derer A, Schinke T, Amling M, Schett G, Mielenz D, David J Inhibition of bone remodeling in young mice by bisphosphonate displaces the plasma cell niche into the spleen. J Immunol, 2014-06-04;193(1):223-33. 2014-06-04 [PMID: 24899506] (Mouse)
• Yoo Y, Kwag J, Kim K, Kim C Effects of neuropeptides and mechanical loading on bone cell resorption in vitro. Int J Mol Sci, 2014-04-08;15(4):5874-83. 2014-04-08 [PMID: 24717410] (Mouse)
• Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, Eriksen E, Syversen U Effects of the peroxisome proliferator-activated receptor (PPAR)-delta agonist GW501516 on bone and muscle in ovariectomized rats. Endocrinology, 2014-04-07;155(6):2178-89. 2014-04-07 [PMID: 24708238] (Rat)
• Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, Schwartz H, Schoenecker J Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res, 2014-06-01;29(6):1431-45. 2014-06-01 [PMID: 24443409] (Mouse)
• Teramachi J, Zhou H, Subler M, Kitagawa Y, Galson D, Dempster D, Windle J, Kurihara N, Roodman G Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone. J Bone Miner Res, 2014-06-01;29(6):1456-65. 2014-06-01 [PMID: 24339057] (Mouse)
• Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel N, Swain F, Skinner R, Eyre D, Gaddy D, Suva L, Morello R Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis. J Bone Miner Res, 2014-03-01;29(3):666-75. 2014-03-01 [PMID: 23959653] (Mouse)
• Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, Van Dyke T, Gyurko R Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol, 2012-12-14;190(2):689-94. 2012-12-14 [PMID: 23241890] (Mouse)
• Buckle , Clive He, De Leenheer , Evy, Lawson , Michelle, Yong , Kwee, Rabin , Neil, Perry , Mark, Vanderkerken , Karen, Croucher , Peter Ia Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma. PLoS ONE, 2012-08-29;7(8):e41127. 2012-08-29 [PMID: 22952578] (Mouse)
• Onal M, Xiong J, Chen X, Thostenson J, Almeida M, Manolagas S Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. Oncogene, 2012-07-10;287(35):29851-60. 2012-07-10 [PMID: 22782898] (Mouse)
• Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H Osteoprotection by semaphorin 3A. Nature, 2012-05-03;485(7396):69-74. 2012-05-03 [PMID: 22522930] (Mouse)
• Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway. Acta Pharmacol. Sin., 2012-03-19;33(4):479-89. 2012-03-19 [PMID: 22426695] (Rat)
• Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol. Endocrinol., 2011-12-29;26(2):341-8. 2011-12-29 [PMID: 22207718] (Mouse)
• Chao C, Joyce-Shaikh B, Grein J C17 prevents inflammatory arthritis and associated joint destruction in mice. PLoS ONE, 2011-07-25;6(7):e22256. 2011-07-25 [PMID: 21799806] (Mouse)
• Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans. J. Bone Miner. Res., 2011-08-01;26(8):1891-903. 2011-08-01 [PMID: 21509823] (Mouse)
• Mentrup B, Marschall C, Barvencik F, Amling M, Plendl H, Jakob F, Beck C Functional characterization of a novel mutation localized in the start codon of the tissue-nonspecific alkaline phosphatase gene. Bone, 2011-03-16;48(6):1401-8. 2011-03-16 [PMID: 21419245] (Rat)
• Ho TY, Santora K, Chen JC, Frankshun AL, Bagnell CA Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis. Bone, 2011-03-16;48(6):1346-53. 2011-03-16 [PMID: 21419242] (Rat)
• Sample SJ, Collins RJ, Wilson AP, Racette MA, Behan M, Markel MD, Kalscheur VL, Hao Z, Muir P Systemic effects of ulna loading in male rats during functional adaptation. J. Bone Miner. Res., 2010-09-01;25(9):2016-28. 2010-09-01 [PMID: 20499374] (Rat)
• Neunaber C, Catala-Lehnen P, Beil FT Increased trabecular bone formation in mice lacking the growth factor midkine. J. Bone Miner. Res., 2010-08-01;25(8):1724-35. 2010-08-01 [PMID: 20200993] (Mouse)
• Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. Blood, 2009-07-24;114(15):3216-26. 2009-07-24 [PMID: 19633200] (Mouse)
• O'Connor RD, Zayzafoon M, Farach-Carson MC, Schanen NC Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome. Bone, 2009-05-03;45(2):346-56. 2009-05-03 [PMID: 19414073] (Mouse)
• Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone, 2009-04-18;45(2):309-20. 2009-04-18 [PMID: 19379851] (Mouse)
• Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J. Bone Miner. Res., 2009-05-01;24(5):775-84. 2009-05-01 [PMID: 19113915] (Mouse)
• Valverde P, Zhang J, Fix A, Zhu J, Ma W, Tu Q, Chen J Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in mice. J. Bone Miner. Res., 2008-11-01;23(11):1775-88. 2008-11-01 [PMID: 18597627] (Mouse)
• Garlet GP, Cardoso CR, Campanelli AP, Garlet TP, Avila-Campos MJ, Cunha FQ, Silva JS The essential role of IFN-gamma in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice. Microbes Infect., 2008-01-25;10(5):489-96. 2008-01-25 [PMID: 18403243] (Mouse)
• Liu J, Xu K, Wen G, Guo H, Li S, Wu X, Dai R, Sheng Z, Liao E Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice. Bone, 2008-02-08;42(5):950-9. 2008-02-08 [PMID: 18337202] (Mouse)
• Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood, 2008-02-27;112(1):196-207. 2008-02-27 [PMID: 18305214] (Human, Mouse)
• Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation, 2008-01-02;117(3):411-20. 2008-01-02 [PMID: 18172035] (Mouse)
• Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J. Immunol., 2007-07-01;179(1):639-46. 2007-07-01 [PMID: 17579086] (Mouse)
• Brechter AB, Lerner UH Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum., 2007-03-01;56(3):910-23. 2007-03-01 [PMID: 17328065] (Mouse)
• Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian WP, Weitzmann MN B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood, 2007-01-03;109(9):3839-48. 2007-01-03 [PMID: 17202317] (Mouse)
• Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, Mizoguchi T, Sato M, Mogi M, Penninger JM, Takahashi N Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J. Immunol., 2007-01-01;178(1):192-200. 2007-01-01 [PMID: 17182555] (Mouse)
• Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL, Fu WM Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J. Biol. Chem., 2006-11-10;282(4):2346-54. 2006-11-10 [PMID: 17099218] (Mouse)
• Sato M, Nakamichi Y, Nakamura M, Sato N, Ninomiya T, Muto A, Nakamura H, Ozawa H, Iwasaki Y, Kobayashi E, Shimizu M, DeLuca HF, Takahashi N, Udagawa N New 19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 analogs strongly stimulate osteoclast formation both in vivo and in vitro. Bone, 2006-10-25;40(2):293-304. 2006-10-25 [PMID: 17070129] (Mouse)

FAQs for TRANCE/TNFSF11/RANK L (MTR00). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Tnfsf11