Mouse Total MMP-3 Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse Total MMP-3 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse MMP-3 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure total mouse MMP-3 (pro-, active, and TIMP-complexed MMP-3) in cell culture supernates and mouse serum. It contains NS0-expressed recombinant mouse MMP-3 and antibodies raised against the recombinant factor. Both antibodies also recognize recombinant mouse active MMP-3. Natural mouse MMP-3 showed dose-r...esponse curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative levels of natural mouse MMP-3.
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• Specificity: Natural and recombinant mouse MMP-3 (pro-, active, and TIMP-complexed)
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Mmp3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Total MMP-3 Quantikine ELISA Kit

• CHDS6
• EC 3.4.24
• EC 3.4.24.17
• matrix metallopeptidase 3 (stromelysin 1, progelatinase)
• matrix metalloproteinase 3 (stromelysin 1, progelatinase)
• Matrix metalloproteinase-3
• MGC126102
• MGC126103
• MMP3
• MMP-3
• proteoglycanase
• SL-1
• STMY
• STMY1MGC126104
• STR1
• Stromelysin 1
• stromelysin-1
• transin-1

Background

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for MMP-3 (MMP300)(13)

Publications using MMP300

• Sambale, M;Lively, S;Espin-Garcia, O;Potla, P;Pastrello, C;Bödecker, S;Wessendorf, L;Kleimann, S;Paruzel, P;Asgarian, R;Tosun, A;Intemann, J;Bertrand, J;Dell'Accio, F;Kapoor, M;Pap, T;Sherwood, J; TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis JCI insight 2024-12-24 [PMID: 39718827] (Mouse)
• Jiang, SY;Tian, T;Yao, H;Xia, XM;Wang, C;Cao, L;Hu, G;Du, RH;Lu, M; The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson's disease via LCN2-dependent astrocyte senescence Cell death and differentiation 2023-08-26 [PMID: 37633968] (Mouse)
• LM Christman, GP Wang, TL Washington, L Gu Muscadine Grape (Vitis rotundifolia) and Wine Polyphenols Alleviated Arthritis and Restored the Gut Microbial Composition in Mice The Journal of nutritional biochemistry, 2023-03-04;0(0):109311. 2023-03-04 [PMID: 36878329] (Mouse)
• D D'Amico, M Olmer, AM Fouassier, P Valdés, PA Andreux, C Rinsch, M Lotz Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis Aging Cell, 2022-07-01;0(0):e13662. 2022-07-01 [PMID: 35778837] (Mouse)
• K Thümmler, E Rom, T Zeis, M Lindner, S Brunner, JJ Cole, D Arseni, S Mücklisch, JM Edgar, N Schaeren-W, A Yayon, C Linington Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential Acta Neuropathol Commun, 2019-12-19;7(1):212. 2019-12-19 [PMID: 31856924] (Mouse)
• T Inoue, M Kohno, H Nagahara, K Murakami, T Sagawa, A Kasahara, S Kaneshita, T Kida, K Fujioka, M Wada, H Nakada, T Hla, Y Kawahito Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production PLoS ONE, 2019-06-07;14(6):e0218090. 2019-06-07 [PMID: 31173610] (Mouse)
• Y Takayama, T Ando, J Ichikawa, H Haro Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs Sci Rep, 2018-07-27;8(1):11320. 2018-07-27 [PMID: 30054581] (Mouse)
• V Schmitt, M Hahn, V Kästele, O Wagner, M Wiendl, A Derer, A Taddeo, S Hahne, A Radbruch, HM Jäck, W Schuh, D Mielenz, S Gay, G Schett, AJ Hueber, S Frey Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts Eur. J. Immunol., 2017-09-22;0(0):. 2017-09-22 [PMID: 28857172] (Mouse)
• Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA Activation of matrix metalloproteinases following anti-Abeta immunotherapy; implications for microhemorrhage occurrence. J Neuroinflammation, 2011-09-09;8(0):115. 2011-09-09 [PMID: 21906275] (Mouse)
• Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A., 2011-08-08;108(34):14222-7. 2011-08-08 [PMID: 21825138] (Mouse)
• Hayer S, Pundt N, Peters MA, Wunrau C, Kuhnel I, Neugebauer K, Strietholt S, Zwerina J, Korb A, Penninger J, Joosten LA, Gay S, Ruckle T, Schett G, Pap T PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J., 2009-09-04;23(12):4288-98. 2009-09-04 [PMID: 19734303] (Mouse)
• Chen L, Belton RJ, Nowak RA Basigin-mediated gene expression changes in mouse uterine stromal cells during implantation. Endocrinology, 2008-10-01;150(2):966-76. 2008-10-01 [PMID: 18832103] (Mouse)
• Davis DR, Wilson K, Sam MJ, Kennedy SE, Mackman N, Charlesworth JA, Erlich JH The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator. J. Mol. Cell. Cardiol., 2007-01-17;42(3):559-71. 2007-01-17 [PMID: 17234207] (Mouse)

Bioinformatics

• Gene Symbol: Mmp3