Human Pro-MMP-10 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Pro-MMP-10 Quantikine ELISA Kit Summary

Background
The Quantikine Human Pro-MMP-10 Immunoassay is a 4.5 hour solid phase immunoassay designed to measure pro-MMP-10 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human pro-MMP-10 and antibodies raised against the recombinant protein. This kit will not detect human active MMP-10 existing in either free or TIMP-bound form. Natural human pro-MMP-10 showed dos...e-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human pro-MMP-10.
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Specificity
Natural and recombinant human pro-MMP-10
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
MMP10

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DM1000.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Pro-MMP-10 Quantikine ELISA Kit

  • EC 3.4.24
  • EC 3.4.24.22
  • matrix metallopeptidase 10 (stromelysin 2)
  • matrix metalloprotease 10
  • matrix metalloproteinase 10 (stromelysin 2)
  • Matrix metalloproteinase-10
  • MMP10
  • MMP-10
  • SL-2
  • STMY2stromelysin-2
  • Stromelysin 2
  • transin 2
  • transin-2

Background

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for MMP-10 (DM1000)(12)

We have publications tested in 1 confirmed species: Human.


Filter By Application
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Human
(12)
All Species
Showing Publications 1 - 10 of 12. Show All 12 Publications.
Publications using DM1000 Applications Species
JM Mora-Gutié, JA Rodríguez, MA Fernández-, J Orbe, FJ Escalada, MJ Soler, MF Slon Roble, M Riera, JA Páramo, N Garcia-Fer MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade Sci Rep, 2020;10(1):26. 2020 [PMID: 31913319] (Human) Human
Shimizu Y, Furuya H, Bryant Greenwood P, Chan O, Dai Y, Thornquist M, Goodison S, Rosser C A multiplex immunoassay for the non-invasive detection of bladder cancer. J Transl Med, 2016;14(1):31. 2016 [PMID: 26830497] (Human) Human
Chen, Chang-Ha, Chang, Alice Y, Li, Shau-Hsu, Tsai, Hsin-Tin, Shiu, Li-Yen, Su, Li-Jen, Wang, Wen-Lung, Chiu, Tai-Jen, Luo, Sheng-De, Huang, Tai-Lin, Chien, Chih-Yen Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer. Mol Cancer, 2015;14(0):83. 2015 [PMID: 25889801] (Human) Human
Du X, Lin B, Wang Q, Li H, Ingalla E, Tien J, Rooney I, Ashkenazi A, Penuel E, Qing J MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer. Clin Cancer Res, 2014;20(24):6324-35. 2014 [PMID: 25326231] (Human) Human
Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur. J. Haematol., 2010;84(3):239-51. 2010 [PMID: 19922462] (Human) Human
Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, Belmonte F, Medina JC, Lliminana MC, Ferrer-Aguero JM, Ferreres J, Mora ML, Lubillo S, Sanchez M, Barrios Y, Sierra A, Paramo JA Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care, 2009;13(5):R158. 2009 [PMID: 19799791] (Human) Human
McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert RE Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? Kidney Int., 2007;72(4):481-8. 2007 [PMID: 17554258] (Human) Human
Barksby HE, Milner JM, Patterson AM, Peake NJ, Hui W, Robson T, Lakey R, Middleton J, Cawston TE, Richards CD, Rowan AD Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis. Arthritis Rheum., 2006;54(10):3244-53. 2006 [PMID: 17009259] (Human) Human
Montero I, Orbe J, Varo N, Beloqui O, Monreal JI, Rodriguez JA, Diez J, Libby P, Paramo JA C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis. J. Am. Coll. Cardiol., 2006;47(7):1369-78. 2006 [PMID: 16580524] (Human) Human
Behera AK, Hildebrand E, Scagliotti J, Steere AC, Hu LT Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis. Infect. Immun., 2005;73(1):126-34. 2005 [PMID: 15618147] (Human) Human
Show All 12 Publications.

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FAQs for MMP-10 (DM1000). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.
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Bioinformatics

Gene Symbol MMP10