MMP-3 Products

Description

Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis (1). Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. MMP3 (stromelysin) is a secreted metalloprotease with a wide range of substrate specificities. MMP3 is synthesized in a preproenzyme form with a calculated size of 54 kDa and a 17-amino acid long signal peptide. Data indicate that the expression and the possible involvement of secreted metalloproteases in tumorigenesis result from a specific interaction between the transforming factor and the target cell, which may vary in different species (2). In neural studies, matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed dopamine cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. (3).

Bioinformatics

Entrez	171045 Rat 17392 Mouse 4314 Human
Uniprot	NM_002422 Human NP_002413 Human NP_002413.1 Human P08254 Human
Product By Gene ID	4314
Alternate Names	CHDS6 EC 3.4.24 EC 3.4.24.17 matrix metallopeptidase 3 (stromelysin 1, progelatinase) matrix metalloproteinase 3 (stromelysin 1, progelatinase) Matrix metalloproteinase-3 MGC126102 MGC126103 MMP-3 proteoglycanase SL-1 STMY STMY1MGC126104 STR1 stromelysin-1 Transin-1 transin-1

Research Areas for MMP-3

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Extracellular Matrix

Related MMP-3 Blog Posts

Check out the latest blog posts on MMP-3.

MMP3 - a potential target for arthritis therapies Matrix metalloproteinases (MMPs) are responsible for the degradation of extracellular matrix proteins. MMPs are essential for tissue remodeling during normal processes such as embryonic development as well as pathological conditions such as arthri...    Read more.

Read more MMP-3 related blogs.