Mouse TGF-beta 1 DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Mouse TGF-beta 1 DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Tgfb1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY1679.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TGF-beta 1 DuoSet ELISA, 15 Plate

  • CEDLAP
  • DPD1
  • latency-associated peptide
  • TGF beta
  • TGF beta1
  • TGFB
  • TGFB1
  • TGF-beta 1 protein
  • TGFbeta 1
  • TGF-beta 1
  • TGFbeta
  • TGF-beta-1
  • transforming growth factor beta-1
  • transforming growth factor, beta 1

Background

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

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Publications for TGF-beta 1 (DY1679)(170)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.


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Human
(3)
Mouse
(161)
Rat
(5)
Transgenic Mouse
(8)
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Showing Publications 1 - 10 of 170. Show All 170 Publications.
Publications using DY1679 Applications Species
Min, SH;Shin, JH;Park, S;Cui, R;Hur, YJ;Jeong, WH;Kim, SY;Na, Y;Cho, J; Modulation of AMPK/NLRP3 Signaling Mitigates Radiation-Induced Lung Inflammation by a Synthetic Lipoxin A4 Analogue International journal of molecular sciences 2025-11-07 [PMID: 41303320] (Mouse) Mouse
Hoffman, ET;Shah, A;Barboza, WR;Rodriguez, LR;Dherwani, R;Dooley, PE;Minakin, K;Tomer, Y;Ayers, LJ;Jones, D;Murthy, A;Bennett, A;Lange, AN;Bawa, PS;Wang, F;Babu, A;Chavez, K;Nakamoto, RS;Cooper, CH;Basil, MC;Raredon, MSB;Kotton, DN;Alysandratos, KD;Katzen, J; Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models Nature communications 2025-09-30 [PMID: 41027873] (Mouse) Mouse
Hsieh, MH;Lai, PF;Chen, PC;Liu, XL;Chen, WL;Kuo, WS;Wang, SD;Kao, HF;Lin, LJ;Wu, LS;Wang, JY; Exosomal MicroRNA let-7 Modulates Lipid Metabolism and Inflammation in Foamy Macrophages of Chronic Obstructive Pulmonary Disease International journal of molecular sciences 2025-09-10 [PMID: 41009372] (Mouse) Mouse
Stephens, JQ;Blas-Machado, U;Sherrill, C;Caudell, D;Kock, N;Davis, AM;Whitfield, JM;Hart, B;Kavanagh, K; Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events Frontiers in pharmacology 2025-04-02 [PMID: 40242438] (Mouse) Mouse
Schwab, AD;Wyatt, TA;Schanze, OW;Nelson, AJ;Gleason, AM;Duryee, MJ;Mosley, DD;Thiele, GM;Mikuls, TR;Poole, JA; Lung-delivered IL-10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice Physiological reports 2025-02-01 [PMID: 39980189] (Mouse) Mouse
Choi, YJ;Kim, MJ;Lee, YJ;Choi, M;Shim, WS;Park, M;Kim, YC;Kang, KW; Prevention of radiotherapy-induced pro-tumorigenic microenvironment by SFK inhibitors Theranostics 2025-01-01 [PMID: 39776795] (Mouse) Mouse
Becker, IC;Barrachina, MN;Lykins, J;Camacho, V;Stone, AP;Chua, BA;Signer, RAJ;Machlus, KR;Whiteheart, SW;Roweth, HG;Italiano, JE; Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice bioRxiv : the preprint server for biology 2024-12-05 [PMID: 39677616] (Mouse) Mouse
Hussain, S;Majumder, N;Mazumder, MHH;Lewis, SE;Olapeju, O;Velayutham, M;Amin, MS;Brundage, K;Kelley, EE;Vanoirbeek, J; Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype Redox biology 2024-10-01 [PMID: 39244793] (Mouse) Mouse
Blanco, T;Nakagawa, H;Musayeva, A;Krauthammer, M;Singh, RB;Narimatsu, A;Ge, H;Shoushtari, SI;Dana, R; Acquired Immunostimulatory Phenotype of Migratory CD103+ Dendritic Cells Promotes Alloimmunity Following Corneal Transplantation JCI insight 2024-09-05 [PMID: 39235864] (Mouse) Mouse
Munguia-Galaviz, FJ;Miranda-Diaz, AG;Gutierrez-Mercado, YK;Ku-Centurion, M;Gonzalez-Gonzalez, RA;Portilla-de Buen, E;Echavarria, R; The Sigma-1 Receptor Exacerbates Cardiac Dysfunction Induced by Obstructive Nephropathy: A Role for Sexual Dimorphism Biomedicines 2024-08-20 [PMID: 39200372] (Mouse) Mouse
Show All 170 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for TGF-beta 1 (DY1679). (Showing 1 - 1 of 1 FAQs).

  1. What is the difference between the Quantikine and Duoset ELISA kits?
    • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Additional TGF-beta 1 Products

Blogs on TGF-beta 1.

TGF-beta 1 - a versatile signaling molecule with roles in development and disease
The transforming growth factor-beta (TGF-beta) family consists of a wide variety of signaling proteins with roles in development. TGF-beta signaling controls growth, differentiation, and immune responses and is often misregulated in cancer. TGF-beta ...  Read full blog post.

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Bioinformatics

Gene Symbol Tgfb1