Mouse sVEGFR1/Flt-1 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse sVEGFR1/Flt-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Flt1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse sVEGFR1/Flt-1 DuoSet ELISA, 15 Plate

• EC 2.7.10
• EC 2.7.10.1
• FLT
• FLT1
• Flt-1
• Fms-like tyrosine kinase 1
• fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor)
• FRT
• Tyrosine-protein kinase FRT
• Tyrosine-protein kinase receptor FLT
• vascular endothelial growth factor receptor 1
• Vascular permeability factor receptor
• VEGF R1
• VEGFR1
• VEGFR-1

Background

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Publications for VEGFR1/Flt-1 (DY471)(9)

Publications using DY471

• N Rei, CA Valente, SH Vaz, M Farinha-Fe, JA Ribeiro, AM Sebastião Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine PLoS ONE, 2022-12-14;17(12):e0272104. 2022-12-14 [PMID: 36516126] (Mouse)
• N de Alwis, NK Binder, YTM Mangwiro, S Beard, N Pritchard, E Kadife, BR Fato, E Keenan, FC Brownfoot, TJ Kaitu'u-Li, NJ Hannan Actions of Esomeprazole on the Maternal Vasculature in Lean and Obese Pregnant Mice with Impaired Nitric Oxide Synthesis: A Model of Preeclampsia International Journal of Molecular Sciences, 2022-07-25;23(15):. 2022-07-25 [PMID: 35897759] (Mouse)
• S Liong, O Oseghale, EE To, K Brassingto, JR Erlich, R Luong, F Liong, R Brooks, C Martin, S O'Toole, A Vinh, LAJ O'Neill, S Bozinovski, R Vlahos, PC Papagianis, JJ O'Leary, DA Brooks, S Selemidis Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice Proc. Natl. Acad. Sci. U.S.A., 2020-09-21;0(0):. 2020-09-21 [PMID: 32958663] (Mouse)
• RR Zhu, Q Chen, ZB Liu, HG Ruan, QC Wu, XL Zhou Inhibition of the Notch1 pathway induces peripartum cardiomyopathy J. Cell. Mol. Med., 2020-06-11;0(0):. 2020-06-11 [PMID: 32529705] (Mouse)
• DR Addis, JA Lambert, C Ren, S Doran, S Aggarwal, T Jilling, S Matalon Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice J Am Heart Assoc, 2020-02-03;9(3):e013238. 2020-02-03 [PMID: 32009528] (Mouse)
• M Verma, Y Shimizu-Mo, Y Asakura, JP Ennen, J Bosco, Z Zhou, GH Fong, S Josiah, D Keefe, A Asakura Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy PLoS Genet., 2019-12-26;15(12):e1008468. 2019-12-26 [PMID: 31877123] (Mouse)
• JA Lambert, MA Carlisle, A Lam, S Aggarwal, S Doran, C Ren, WE Bradley, L Dell'Itali, N Ambalavana, DA Ford, RP Patel, T Jilling, S Matalon Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice Hypertension, 2017-06-12;0(0):. 2017-06-12 [PMID: 28607126] (Mouse)
• Zhao Y, Olonisakin T, Xiong Z, Hulver M, Sayeed S, Yu M, Gregory A, Kochman E, Chen B, Mallampalli R, Sun M, Silverstein R, Stolz D, Shapiro S, Ray A, Ray P, Lee J Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. Mucosal Immunol, 2014-12-10;8(4):896-905. 2014-12-10 [PMID: 25492474] (Mouse)
• Craici , Iasmina, Wagner , Steven J, Weissgerber , Tracey L, Grande , Joseph P, Garovic , Vesna D Advances in the pathophysiology of pre-eclampsia and related podocyte injury. Kidney Int, 2014-02-26;86(2):275-85. 2014-02-26 [PMID: 24573315] (Rat)

FAQs for VEGFR1/Flt-1 (DY471). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Flt1