Mouse/Rat TNF RI/TNFRSF1A Quantikine ELISA Kit

• Reactivity: Mu, Rt
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat TNF RI/TNFRSF1A Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse/Rat TNF RI immunoassay is a 4.5 hour solid-phase ELISA designed to measure TNF RI in mouse or rat cell culture supernates and serum. It contains E. coli-expressed recombinant mouse TNF RI and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse TNF RI. Results obtained using natural mous...e or rat TNF RI showed dose response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural TNF RI.
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• Specificity: Natural and recombinant mouse and rat TNF RI
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnfrsf1a

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat TNF RI/TNFRSF1A Quantikine ELISA Kit

• CD120a antigen
• CD120a
• FPF
• p55
• p55-R
• p60
• TNF RI
• TNFARMGC19588
• TNF-R
• TNF-R1
• TNFR1TBP1
• TNFR55
• TNF-R55
• TNFR60
• TNFRI
• TNF-RI
• TNF-R-I
• TNFR-I
• TNFRSF1A
• tumor necrosis factor binding protein 1
• Tumor necrosis factor receptor 1
• tumor necrosis factor receptor 1A isoform beta
• tumor necrosis factor receptor superfamily member 1A
• tumor necrosis factor receptor superfamily, member 1A
• tumor necrosis factor receptor type 1
• Tumor necrosis factor receptor type I
• tumor necrosis factor-alpha receptor

Background

TNF RI (TNF receptor 1; TNF R-p55/p60) is a transmembrane receptor for TNF-alpha and Lymphotoxin-alpha/TNF-beta. A soluble decoy form of the receptor is shed by ADAM-17/TACE in response to inflammatory stimulation. TNF RI signaling through NFkB is essential for the development of lymph node germinal centers and Peyer’s patches and for combating intracellular pathogens such as Listeria.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TNF RI/TNFRSF1A (MRT10)(31)

Publications using MRT10

• Y Zheng, NZ Prince, LN Peralta Ma, S Ahmed, J Garssen, P Perez Pard, AD Kraneveld The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10 International Journal of Molecular Sciences, 2022;23(19):. 2022 [PMID: 36232346] (Mouse)
• N Ge, R Westbrook, J Langdon, H Yang, R Marx, P Abadir, QL Xue, JD Walston Plasma levels of corticosterone, tumor necrosis factor receptor 1 and interleukin 6 are influenced by age, sex and chronic inflammation in mice treated with acute temperature stress Exp Gerontol, 2020;142(0):111136. 2020 [PMID: 33164891] (Mouse)
• Z Li, M Murakoshi, S Ichikawa, T Koshida, E Adachi, C Suzuki, S Ueda, T Gohda, Y Suzuki The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice FEBS Open Bio, 2020;0(0):. 2020 [PMID: 33098615] (Mouse)
• A Aguilar-Va, N Haji, D De Gregori, E Matta-Cama, MJ Eslamizade, J Popic, V Sharma, R Cao, C Rummel, A Tanti, S Wiebe, N Nuñez, S Comai, R Nadon, G Luheshi, N Mechawar, G Turecki, JC Lacaille, G Gobbi, N Sonenberg Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E Nat Commun, 2018;9(1):2459. 2018 [PMID: 29941989] (Mouse)
• MKE Ougaard, PH Kvist, HE Jensen, C Hess, I Rune, H Søndergaar Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease Int J Nephrol, 2018;2018(0):8424502. 2018 [PMID: 29692933] (Mouse)
• JN Khantakova, AN Silkov, VP Tereshchen, EV Gavrilova, RA Maksyutov, SV Sennikov Transfection of bone marrow derived cells with immunoregulatory proteins Cytokine, 2018;108(0):82-88. 2018 [PMID: 29579547] (Mouse)
• J Ezpeleta, F Boudet-Dev, M Pietri, A Baudry, V Baudouin, A Alleaume-B, N Dagoneau, O Kellermann, JM Launay, B Schneider Protective role of cellular prion protein against TNF?-mediated inflammation through TACE ?-secretase Sci Rep, 2017;7(1):7671. 2017 [PMID: 28794434] (Mouse)
• L Ge, NL Vujanovic Soluble TNF Regulates TACE via AP-2? Transcription Factor in Mouse Dendritic Cells J. Immunol., 2017;198(1):417-427. 2017 [PMID: 27852742] (Mouse)
• Awad A, You H, Gao T, Cooper T, Nedospasov S, Vacher J, Wilkinson P, Farrell F, Brian Reeves W Macrophage-derived tumor necrosis factor-alpha mediates diabetic renal injury. Kidney Int, 2015;88(4):722-33. 2015 [PMID: 26061548]
• Frohbergh M, Ge Y, Meng F, Karabul N, Solyom A, Lai A, Iatridis J, Schuchman E, Simonaro C Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment. PLoS ONE, 2014;9(6):e100882. 2014 [PMID: 24964042] (Rat)
• Heard M, Simmons C, Simmen F, Simmen R Kruppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis. Endocrinology, 2014;155(4):1532-46. 2014 [PMID: 24476135] (Mouse)
• Mallipattu S, Liu R, Zhong Y, Chen E, D'Agati V, Kaufman L, Ma'ayan A, Klotman P, Chuang P, He J Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney Int, 2013;83(4):626-34. 2013 [PMID: 23325078] (Mouse)
• Bruggeman LA, Drawz PE, Kahoud N, Lin K, Barisoni L, Nelson PJ TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. Lab. Invest., 2011;91(3):413-25. 2011 [PMID: 21221075] (Mouse)
• Murthy A, Defamie V, Smookler DS Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J. Clin. Invest., 2010;120(8):2731-44. 2010 [PMID: 20628198] (Mouse)
• Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J. Bone Miner. Res., 2010;25(1):114-23. 2010 [PMID: 19580462] (Mouse)
• Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy. Exp. Hematol., 2009;37(8):969-78. 2009 [PMID: 19486922] (Mouse)
• Olleros ML, Martin ML, Vesin D, Fotio AL, Santiago-Raber ML, Rubbia-Brandt L, Spahr L, Hadengue A, Garcia I Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. Cytokine, 2008;44(1):118-25. 2008 [PMID: 18722787] (Mouse)
• Voskas D, Babichev Y, Ling LS, Alami J, Shaked Y, Kerbel RS, Ciruna B, Dumont DJ An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. J. Leukoc. Biol., 2008;84(1):59-67. 2008 [PMID: 18443190] (Mouse)
• Lahat N, Rahat MA, Kinarty A, Weiss-Cerem L, Pinchevski S, Bitterman H Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages. Am. J. Physiol., Cell Physiol., 2008;295(1):C2-12. 2008 [PMID: 18434619] (Mouse)
• Canault M, Leroyer AS, Peiretti F, Leseche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am. J. Pathol., 2007;171(5):1713-23. 2007 [PMID: 17872973] (Mouse)
• Wilson MR, Goddard ME, O'Dea KP, O'Dea KP, Choudhury S, Takata M Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L60-8. 2007 [PMID: 17435079] (Mouse)
• Frances R, Chiva M, Sanchez E, Gonzalez-Navajas JM, Llovet T, Zapater P, Soriano G, Munoz C, Balanzo J, Perez-Mateo M, Song XY, Guarner C, Such J Bacterial translocation is downregulated by anti-TNF-alpha monoclonal antibody administration in rats with cirrhosis and ascites. J. Hepatol., 2007;46(5):797-803. 2007 [PMID: 17321632] (Rat)
• Tellier E, Rebsomen L The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res., 2006;312(20):3969-80. 2006 [PMID: 17010968] (Mouse)
• Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J. Cell. Physiol., 2006;208(2):363-72. 2006 [PMID: 16619241] (Mouse)
• Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J. Clin. Invest., 2006;116(4):984-95. 2006 [PMID: 16585964] (Mouse)
• D'hulst AI, Bracke KR, Maes T, De Bleecker JL, Pauwels RA, Joos GF, Brusselle GG Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema. Eur. Respir. J., 2006;28(1):102-12. 2006 [PMID: 16540505] (Mouse)
• Petelin M, Naruishi K, Shiomi N, Mineshiba J, Arai H, Nishimura F, Takashiba S, Murayama Y Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice. Exp. Mol. Pathol., 2004;76(1):76-81. 2004 [PMID: 14738872] (Human)
• Hildebrandt GC, Duffner UA, Olkiewicz KM, Corrion LA, Willmarth NE, Williams DL, Clouthier SG, Hogaboam CM, Reddy PR, Moore BB, Kuziel WA, Liu C, Yanik G, Cooke KR A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood, 2004;103(6):2417-26. 2004 [PMID: 14615370] (Mouse)
• Doerschug K, Sanlioglu S, Flaherty DM, Wilson RL, Yarovinsky T, Monick MM, Engelhardt JF, Hunninghake GW First-generation adenovirus vectors shorten survival time in a murine model of sepsis. J. Immunol., 2002;169(11):6539-45. 2002 [PMID: 12444165] (Mouse)
• Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol., 2001;31(7):2104-15. 2001 [PMID: 11449364] (Mouse)
• Jin L, Raymond DP, Crabtree TD, Pelletier SJ, Houlgrave CW, Pruett TL, Sawyer RG Enhanced murine macrophage TNF receptor shedding by cytosine-guanine sequences in oligodeoxynucleotides. J. Immunol., 2000;165(9):5153-60. 2000 [PMID: 11046047] (Mouse)

Bioinformatics

• Gene Symbol: Tnfrsf1a