Mouse RAGE DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse RAGE DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ager

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse RAGE DuoSet ELISA, 15 Plate

• advanced glycosylation end product-specific receptor
• AGER
• RAGE isoform delta
• RAGE isoform sRAGE-delta
• RAGE
• Receptor for advanced glycosylation end products
• receptor for advanced glycosylation end-products
• SCARJ1

Background

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

Publications for AGER (DY1179)(9)

Publications using DY1179

• Sharma, L;Singh, RB;Ngeow, C;van der Geest, R;Duray, AM;Tolman, NJ;McVerry, BJ;Dela Cruz, CS;Alcorn, JF;Bain, W;Robinson, KM; Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice Physiological reports 2025-02-01 [PMID: 39921246] (Mouse)
• A Kindermann, L Binder, J Baier, B Gündel, A Simm, R Haase, B Bartling Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation BMC Pulm Med, 2019-12-16;19(1):245. 2019-12-16 [PMID: 31842840] (Mouse)
• Kagedan D, Lecker I, Batruch I Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry. Clin Proteomics, 2012-02-06;9(1):2. 2012-02-06 [PMID: 22309592] (Rabbit)
• Mallidis C, Czerwiec A, Filippi S, O'Neill J, Maggi M, McClure N Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism. Reproduction, 2011-04-04;142(1):63-71. 2011-04-04 [PMID: 21464116] (Rabbit)
• Lee JS, Su X, Rackley C, Matthay MA, Gupta N Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken), 2010-11-16;294(1):165-72. 2010-11-16 [PMID: 21157927] (Mouse)
• van Zoelen MA, Achouiti A, Schmidt AM, Yang H, Florquin S, Tracey KJ, van der Poll T Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis. Crit. Care Med., 2010-06-01;38(6):1414-22. 2010-06-01 [PMID: 20386310] (Mouse)
• Kuhla A, Hettwer C, Menger MD Oxidative stress-associated rise of hepatic protein glycation increases inflammatory liver injury in uncoupling protein-2 deficient mice. Lab. Invest., 2010-04-05;90(8):1189-98. 2010-04-05 [PMID: 20368701] (Mouse)
• Tan AL, Sourris KC, Harcourt BE, Thallas-Bonke V, Penfold S, Andrikopoulos S, Thomas MC, O'Brien RC, Bierhaus A, Cooper ME, Forbes JM, Coughlan MT Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. Am. J. Physiol. Renal Physiol., 2009-12-16;298(3):F763-70. 2009-12-16 [PMID: 20015941] (Mouse)
• Dave SH, Tilstra JS, Matsuoka K, Li F, DeMarco RA, Beer-Stolz D, Sepulveda AR, Fink MP, Lotze MT, Plevy SE Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J. Leukoc. Biol., 2009-05-19;86(3):633-43. 2009-05-19 [PMID: 19454652] (Mouse)

FAQs for AGER (DY1179). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Ager