Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit



Product Details

Reactivity MuSpecies Glossary
Applications ELISA

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Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit Summary

The Quantikine Mouse OPG Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse OPG in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse OPG and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse OPG accurately. Results obtained using natural mouse OPG showed dose response that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse OPG.
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Natural and recombinant mouse OPG
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
Interference observed with 1 or more available related molecules.
Read Publications using MOP00.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit

  • OCIF
  • OCIFMGC29565
  • OPG
  • OPGtumor necrosis factor receptor superfamily member 11B
  • Osteoclastogenesis inhibitory factor
  • Osteoprotegerin
  • TR1
  • tumor necrosis factor receptor superfamily, member 11b


Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for Osteoprotegerin/TNFRSF11B (MOP00)(56)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

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Showing Publications 1 - 10 of 56. Show All 56 Publications.
Publications using MOP00 Applications Species
E Cho, X Che, MJ Ang, S Cheon, J Lee, KS Kim, CH Lee, SY Lee, HY Yang, C Moon, C Park, JY Choi, TH Lee Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration Elife, 2023-02-03;12(0):. 2023-02-03 [PMID: 36735291] (Mouse) Mouse
C Polan, C Brenner, M Herten, G Hilken, F Grabellus, HL Meyer, M Burggraf, M Dudda, W Jahnen-Dec, C Wedemeyer, MD Kauther Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice Journal of functional biomaterials, 2023-01-04;14(1):. 2023-01-04 [PMID: 36662077] (Mouse) Mouse
J Yong, S Gröger, J von Bremen, S Ruf Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment International Journal of Molecular Sciences, 2022-08-18;23(16):. 2022-08-18 [PMID: 36012576] (Mouse) Mouse
JJ Wu, ZL Sun, SY Liu, ZH Chen, ZD Yuan, ML Zou, YY Teng, YY Li, DY Guo, FL Yuan The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis Cell Death & Disease, 2022-06-06;13(6):527. 2022-06-06 [PMID: 35661105] (Human) Human
M Smeda, KM Galler, M Woelflick, A Rosendahl, C Moehle, B Lenhardt, W Buchalla, M Widbiller Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells International Journal of Molecular Sciences, 2022-02-27;23(5):. 2022-02-27 [PMID: 35269758] (Human) Human
JJM Junqueira, JD Lourenço, KR da Silva, V Jorgetti, RP Vieira, AA de Araujo, K De Angelis, AT Correia, LHV Alves, IFLC Tibério, AP Barbosa, FDTQDS Lopes Increased bone resorption by long-term cigarette smoke exposure in animal model Heliyon, 2021-12-10;7(12):e08587. 2021-12-10 [PMID: 34977408] (Mouse) Mouse
W Zhao, P Wiedemann, EM Wölfel, M Neven, S Peters, T Imhof, M Koch, B Busse, M Amling, T Schinke, TA Yorgan Decreased Trabecular Bone Mass in Col22a1-Deficient Mice Cells, 2021-11-04;10(11):. 2021-11-04 [PMID: 34831244] (Mouse) Mouse
N Liao, T Koehne, J Tuckermann, I Triviai, M Amling, JP David, T Schinke, J Luther Osteoblast-specific inactivation of p53 results in locally increased bone formation PLoS ONE, 2021-11-18;16(11):e0249894. 2021-11-18 [PMID: 34793446] (Mouse) Mouse
EJ Lee, W Na, MK Kang, YH Kim, DY Kim, H Oh, SI Kim, SY Oh, S Park, K Park, YH Kang Hydroxycoumarin Scopoletin Inhibits Bone Loss through Enhancing Induction of Bone Turnover Markers in a Mouse Model of Type 2 Diabetes Biomedicines, 2021-06-07;9(6):. 2021-06-07 [PMID: 34200167] (Mouse) Mouse
W Li, C Wei, L Xu, B Yu, Y Chen, D Lu, L Zhang, X Song, L Dong, S Zhou, Z Xu, J Zhu, X Chen, C Su Schistosome infection promotes osteoclast-mediated bone loss PloS Pathogens, 2021-03-18;17(3):e1009462. 2021-03-18 [PMID: 33735306] (Mouse) Mouse
Show All 56 Publications.

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Gene Symbol Tnfrsf11b