Mouse MIF DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse MIF DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Mif

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse MIF DuoSet ELISA, 15 Plate

• EC 5.3.2.1
• EC 5.3.3.12
• GIFmacrophage migration inhibitory factor
• GLIF
• Glycosylation-inhibiting factor
• L-dopachrome isomerase
• L-dopachrome tautomerase
• macrophage migration inhibitory factor (glycosylation-inhibiting factor)
• MIF
• MMIF
• Phenylpyruvate tautomerase

Background

MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. It signals through CXCR4, CXCR7, or complexes of CD74-CD44. MIF exhibits potent paracrine and autocrine stimulatory effects on cell growth and survival and enhances the production of inflammatory cytokines. It also inhibits the effectiveness of immunosuppressive glucocorticoids.

Publications for MIF (DY1978)(15)

Publications using DY1978

• Huang, Y;Chen, L;Li, L;Qi, Y;Tong, H;Wu, H;Xu, J;Leng, L;Cheema, S;Sun, G;Xia, Z;McGuire, J;Rodrigues, B;Young, LH;Bucala, R;Qi, D; Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia JCI insight 2024-07-08 [PMID: 38973609] (Mouse)
• C Ding, R Shrestha, X Zhu, AE Geller, S Wu, MR Woeste, W Li, H Wang, F Yuan, R Xu, JH Chariker, X Hu, H Li, D Tieri, HG Zhang, EC Rouchka, R Mitchell, LJ Siskind, X Zhang, XG Xu, KM McMasters, Y Yu, J Yan Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis Nature Immunology, 2023-01-05;0(0):. 2023-01-05 [PMID: 36604547] (Mouse)
• F Seidel, R Kleemann, W van Duyven, N van Trigt, N Keijzer, S van der Ko, C van Kooten, L Verschuren, A Menke, AJ Kiliaan, J Winter, TR Hughes, BP Morgan, F Baas, K Fluiter, MC Morrison Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-09-14;23(18):. 2022-09-14 [PMID: 36142647] (Mouse)
• MC Morrison, E Gart, WV Duyvenvoor, J Snabel, MJ Nielsen, DJ Leeming, A Menke, R Kleemann Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-02-19;23(4):. 2022-02-19 [PMID: 35216439] (Mouse)
• I Cotzomi-Or, O Nieto-Yañe, I Juárez-Ave, G Rojas-Sánc, JB Montes-Alv, J Reyes-Leyv, P Aguilar-Al, M Rodríguez-, P Maycotte Autophagy inhibition in breast cancer cells induces ROS-mediated MIF expression and M1 macrophage polarization Cellular Signalling, 2021-07-03;0(0):110075. 2021-07-03 [PMID: 34229086] (Mouse)
• A Ulu, A Burr, AJ Heires, J Pavlik, T Larsen, PA Perez, C Bravo, NV DiPatrizio, M Baack, DJ Romberger, TM Nordgren A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts: Role of DHA in repetitive organic dust exposure The Journal of nutritional biochemistry, 2021-06-12;0(0):108797. 2021-06-12 [PMID: 34126202] (Mouse)
• F Virga, F Cappelless, B Stijlemans, AT Henze, R Trotta, J Van Audena, AS Mirchandan, MA Sanchez-Ga, J Vandewalle, F Orso, C Riera-Domi, A Griffa, C Ivan, E Smits, D Laoui, F Martelli, L Langouche, G Van den Be, O Feron, B Ghesquière, H Prenen, C Libert, SR Walmsley, C Corbet, JA Van Ginder, M Ivan, D Taverna, M Mazzone Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation Science Advances, 2021-05-07;7(19):. 2021-05-07 [PMID: 33962944] (Mouse)
• K Phulphagar, LI Kühn, S Ebner, A Frauenstei, JJ Swietlik, J Rieckmann, F Meissner Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis Cell Reports, 2021-03-09;34(10):108826. 2021-03-09 [PMID: 33691121] (Mouse)
• FM de Jesus O, CF Gonçalves-, IMM de Moraes, PA Reis, VN Rocha, PT Bozza, AR Silva, HC de Castro Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis Mediators Inflamm, 2020-10-14;2020(0):1839762. 2020-10-14 [PMID: 33110395] (Mouse)
• I Cotzomi-Or, A Rosas-Cruz, D Ramírez-Ra, J Reyes-Leyv, M Rodriguez-, P Aguilar-Al, P Maycotte Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer Biology (Basel), 2020-01-18;9(1):. 2020-01-18 [PMID: 31963754] (Mouse)
• T Pacheco-Fe, I Juárez-Ave, O Illescas, LI Terrazas, R Hernández-, C Pérez-Plas, EB Gutiérrez-, F Ávila-More, YI Chirino, JL Reyes, V Maldonado, M Rodriguez- Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer Mediators Inflamm., 2019-07-10;2019(0):2056085. 2019-07-10 [PMID: 31360118] (Mouse)
• CA Smith, DJ Tyrell, UA Kulkarni, S Wood, L Leng, RL Zemans, R Bucala, DR Goldstein Macrophage migration inhibitory factor enhances influenza-associated mortality in mice JCI Insight, 2019-07-11;4(13):. 2019-07-11 [PMID: 31292300] (Mouse)
• N Kindt, G Descamps, JR Lechien, M Remmelink, JM Colet, R Wattiez, G Berchem, F Journe, S Saussez Involvement of HPV Infection in the Release of Macrophage Migration Inhibitory Factor in Head and Neck Squamous Cell Carcinoma J Clin Med, 2019-01-10;8(1):. 2019-01-10 [PMID: 30634708] (Mouse)
• B Kim, R Kusibati, T Heisler-Ta, D Mantopoulo, J Ding, MH Abdel-Rahm, AR Satoskar, JP Godbout, SK Bhattachar, CM Cebulla MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment Sci Rep, 2017-10-30;7(1):14336. 2017-10-30 [PMID: 29084983] (Mouse)
• M Rodriguez-, T Cabellos-A, Y Sanchez-Za, I Juárez-Ave, E García-Rey, A Lira-León, JDC Benítez-Fl, T Pacheco-Fe, M Hiriart, EB Gutiérrez- Proinflammatory cytokine MIF plays a role in the pathogenesis of type-2 diabetes mellitus, but does not affect hepatic mitochondrial function Cytokine, 2017-08-02;0(0):. 2017-08-02 [PMID: 28780379] (Mouse)

Bioinformatics

• Gene Symbol: Mif