Mouse IL-15R alpha DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-15R alpha DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il15ra

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-15R alpha DuoSet ELISA, 15 Plate

• CD215 antigen
• CD215
• IL15 R alpha
• IL-15 R alpha
• IL-15 receptor subunit alpha
• IL-15R alpha
• IL15RA
• IL-15Ra
• IL-15R-alpha
• interleukin 15 receptor, alpha
• interleukin-15 receptor subunit alpha
• MGC104179

Background

IL-15 Ra (Interleukin 15 Receptor alpha), also known as CD215, is a transmembrane glycoprotein that plays an important role in NK and CD8+ memory T cell homeostasis and activation. It transmits IL-15 induced signals and additionally interacts with a complex of IL-2 R beta and the common gamma chain (gammaC) which are also subunits of the IL-2 receptor complex. In transpresentation, IL-15/IL-15 Ra complexes are expressed on the surface of one cell and interact with complexes of IL-2 R beta/gammaC on adjacent cells. IL-15/IL-15 Ra complexes can transmit reverse signaling that promotes adhesion and activation of the IL-15/IL-15 Ra expressing cells. Shed soluble forms of IL-15 Ra retain the ability to bind tightly to IL-15 and can inhibit IL-15 bioactivity.

Publications for IL-15R alpha (DY551)(8)

Publications using DY551

• AT Waickman, DL Ligons, S Hwang, JY Park, V Lazarevic, N Sato, C Hong, JH Park CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans Cytokine, 2017-08-12;0(0):. 2017-08-12 [PMID: 28807496] (Mouse)
• R Riff, Y Cohen, H Eini-Rider, O Naamani, J Mazar, YS Haviv, C Chaimovitz, A Douvdevani Systemic inflammatory response syndrome-related lymphopenia is associated with adenosine A1 receptor dysfunction J. Leukoc. Biol., 2017-05-11;0(0):. 2017-05-11 [PMID: 28495790] (Mouse)
• X Xu, Q Sun, X Yu, L Zhao Rescue of nonlytic Newcastle Disease Virus (NDV) expressing IL-15 for cancer immunotherapy Virus Res, 2017-03-07;233(0):35-41. 2017-03-07 [PMID: 28286036] (Mouse)
• Lee GA, Liou YH, Wang SW, Ko KL, Jiang ST, Liao NS Different NK cell developmental events require different levels of IL-15 trans-presentation. J. Immunol., 2011-06-29;187(3):1212-21. 2011-06-29 [PMID: 21715685] (Mouse)
• Zhang M, Yao Z, Dubois S, Ju W, Muller JR, Waldmann TA Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer. Proc. Natl. Acad. Sci. U.S.A., 2009-04-21;106(18):7513-8. 2009-04-21 [PMID: 19383782] (Mouse)
• Mortier E, Woo T, Advincula R, Gozalo S, Ma A IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J. Exp. Med., 2008-05-05;205(5):1213-25. 2008-05-05 [PMID: 18458113] (Mouse)
• Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J. Exp. Med., 2008-02-11;205(2):451-64. 2008-02-11 [PMID: 18268035] (Mouse)
• Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15. J. Biol. Chem., 2007-02-27;282(18):13167-79. 2007-02-27 [PMID: 17327231] (Mouse)

Bioinformatics

• Gene Symbol: Il15ra