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147-IR) inhibits Recombinant Human IL-15 (Catalog # 247-IL) induced proliferation in the CTLL-2 mouse cytotoxic T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human IL-15 (2 ng/mL) activity elicited by Recombinant Human IL-15 Ra Fc Chimera (30 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-15 Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF247). The ND50 is typically 1-4 µg/mL." class="big_lightbox" target="_blank">
AF247) at 3ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-goat IgG VisUCyte HRP Polymer Antibody (Catalog # VC004) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to exocrine glands. " class="big_lightbox" target="_blank">
247-IL) stimulates proliferation in the CTLL‑2 mouse cytotoxic T cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL‑15 (0.8 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL‑15 Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF551). The ND50 is typically 0.3-1.5 µg/mL." class="big_lightbox" target="_blank">
IL15RA is a gene that codes for a protein that is a high-affinity receptor for interleukin-15, and can signal in both cis and trans to neighboring IL2RG-expressing cells, but the expression of different isoforms may interfere with this signal transduction, as isoforms 5-8 do not bind to IL15. The isoforms are all highly expressed in the brain, with isoform 1 being the longest with a 267 amino acid chain and a weight of approximately 28 kDa. Current studies are being done on several diseases and disorders relating to this gene including lymphoma, systemic lupus erythematosus, anemia, inflammatory bowel disease, leukemia, bronchiolitis, rheumatoid arthritis, hepatitis B, gingivitis, lung cancer and Alzheimer's disease. IL15Ra has also been shown to have interactions with SYK, IL2RB, TRAF2, and AXL in pathways such as the IL-15 signlaing, TCR signaling, and IgA production pathways.
![Immunocytochemistry IL-15R alpha Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/IL15_R_alpha_AF247_Immunocytochemistry__Immunofluorescence_23310.jpg)
![N/A IL-15R alpha [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IL15_R_alpha_DY551_ELISA_2114.jpg)
![Immunohistochemistry IL-15R alpha Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/IL-15_R_alpha_AF247_Immunohistochemistry_6752.jpg)
![Neutralization IL-15R alpha Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/IL-15_R_alpha_AF247_Block_Neutralize_605.jpg)
![ELISA IL-15R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af247_human-il-15-r-alpha-affinity-purified-polyclonal-ab-44202415425095.jpg)
![In-situ Hybridization IL-15R alpha Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/af247_human-il-15-r-alpha-affinity-purified-polyclonal-ab-in-situ-hybridization-2352024194228..jpg)
![Flow Cytometry IL-15R alpha Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/af247_human-il-15-r-alpha-affinity-purified-polyclonal-ab-2442026131947.jpg)
