IL-15R alpha Products

Description

IL15RA is a gene that codes for a protein that is a high-affinity receptor for interleukin-15, and can signal in both cis and trans to neighboring IL2RG-expressing cells, but the expression of different isoforms may interfere with this signal transduction, as isoforms 5-8 do not bind to IL15. The isoforms are all highly expressed in the brain, with isoform 1 being the longest with a 267 amino acid chain and a weight of approximately 28 kDa. Current studies are being done on several diseases and disorders relating to this gene including lymphoma, systemic lupus erythematosus, anemia, inflammatory bowel disease, leukemia, bronchiolitis, rheumatoid arthritis, hepatitis B, gingivitis, lung cancer and Alzheimer's disease. IL15Ra has also been shown to have interactions with SYK, IL2RB, TRAF2, and AXL in pathways such as the IL-15 signlaing, TCR signaling, and IgA production pathways.

Bioinformatics

Entrez	3601 Human
Uniprot	NM_002189 Human NM_172200 Human NP_002180 Human Q13261 Human
Product By Gene ID	3601
Alternate Names	CD215 antigen IL-15 receptor subunit alpha IL-15RA IL-15R-alpha interleukin 15 receptor, alpha interleukin-15 receptor subunit alpha MGC104179