Mouse IL-1 alpha/IL-1F1 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-1 alpha/IL-1F1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il1a

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-1 alpha/IL-1F1 DuoSet ELISA, 15 Plate

• BAF
• Hematopoietin-1
• IL1 alpha
• IL-1 alpha
• IL1
• IL1A
• IL-1A
• IL1-ALPHA
• IL1F1
• IL-1F1
• IL1F1hematopoietin-1
• interleukin 1, alpha
• interleukin-1 alpha
• LAF
• LEM
• preinterleukin 1 alpha
• pro-interleukin-1-alpha

Background

IL-1 alpha (Interleukin-1 alpha) is a cytokine that is induced during microbial exposure and promotes the release of multiple inflammatory mediators and acute phase proteins. It also supports hematopoietic stem cell expansion, promotes neutrophil mobilization from the bone marrow, and promotes osteoclast formation. IL-1 alpha signals through a receptor complex composed of IL-1 RI and IL-1 RAcP. It also binds the decoy receptor IL-1 RII which associates with IL-1 RAcP but does not transduce signaling.

Publications for IL-1 alpha/IL-1F1 (DY400)(42)

Publications using DY400

• Yow, SJ;Rosli, SN;Hutchinson, PE;Chen, KW; Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages Cell death & disease 2024-07-04 [PMID: 38965211] (Mouse, Transgenic Mouse)
• Krishnamohan, M;Kaplanov, I;Maudi-Boker, S;Yousef, M;Machluf-Katz, N;Cohen, I;Elkabets, M;Titus, J;Bersudsky, M;Apte, RN;Voronov, E;Braiman, A; Tumor Cell-Associated IL-1? Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment International journal of molecular sciences 2024-04-02 [PMID: 38612760] (Mouse, Transgenic Mouse)
• Mills, KAM;Westermann, F;Espinosa, V;Rosiek, E;Desai, JV;Aufiero, MA;Guo, Y;Mitchell, KA;Tuzlak, S;De Feo, D;Lionakis, MS;Rivera, A;Becher, B;Hohl, TM; GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus bioRxiv : the preprint server for biology 2024-01-04 [PMID: 38260364] (Mouse)
• Leinardi, R;Petriglieri, JR;Pochet, A;Yakoub, Y;Lelong, M;Lescoat, A;Turci, F;Lecureur, V;Huaux, F; Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages International journal of molecular sciences 2023-10-13 [PMID: 37894824] (Transgenic Mouse, Mouse)
• Membrane-bound Interleukin-1 alpha mediates leukocyte adhesion during atherogenesis [PMID: 37701434] (Mouse)
• Pérez-Cabello, JA;Silvera-Carrasco, L;Franco, JM;Capilla-González, V;Armaos, A;Gómez-Lima, M;García-García, R;Yap, XW;Leal-Lasarte, M;Lall, D;Baloh, RH;Martínez, S;Miyata, Y;Tartaglia, GG;Sawarkar, R;García-Domínguez, M;Pozo, D;Roodveldt, C; MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS Proceedings of the National Academy of Sciences of the United States of America 2023-07-11 [PMID: 37399380] (Mouse)
• S Li, Y Fang, Y Zhang, M Song, X Zhang, X Ding, H Yao, M Chen, Y Sun, J Ding, Q Wang, M Lu, G Wu, G Hu Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice Cell Reports, 2022-10-25;41(4):111532. 2022-10-25 [PMID: 36288697] (Mouse)
• N Milad, M Pineault, F Tremblay, J Routhier, A Lechasseur, MJ Beaulieu, S Aubin, MC Morissette Smoking status impacts treatment efficacy in smoke-induced lung inflammation: A pre-clinical study Frontiers in Pharmacology, 2022-09-07;13(0):971238. 2022-09-07 [PMID: 36160400] (Mouse)
• H Choe, BS Hausman, KM Hujer, O Akkus, PN Rather, Z Lee, RA Bonomo, EM Greenfield Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration Oncogene, 2022-06-09;43(0):267-276. 2022-06-09 [PMID: 35678763] (Mouse)
• BY Lee, EKJ Hogg, CR Below, A Kononov, A Blanco-Gom, F Heider, J Xu, C Hutton, X Zhang, T Scheidt, K Beattie, A Lamarca, M McNamara, JW Valle, C Jørgensen Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis Nature Communications, 2021-12-17;12(1):7336. 2021-12-17 [PMID: 34921158] (Mouse)
• FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Cell Reports, 2021-05-25;35(8):109176. 2021-05-25 [PMID: 34038731] (Mouse)
• B Ratitong, M Marshall, E Pearlman &beta-Glucan-stimulated neutrophil secretion of IL-1&alpha is independent of GSDMD and mediated through extracellular vesicles Cell Reports, 2021-05-18;35(7):109139. 2021-05-18 [PMID: 34010648] (Mouse, Transgenic Mouse)
• M Najibi, HH Honwad, JA Moreau, SM Becker, JE Irazoqui A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS Autophagy, 2021-04-13;0(0):. 2021-04-13 [PMID: 33818279] (Mouse)
• S Omori, M Tsugita, Y Hoshikawa, M Morita, F Ito, SI Yamaguchi, Q Xie, O Noyori, T Yamaguchi, A Takada, T Saitoh, S Toyokuni, H Akiba, S Nagata, K Kinoshita, M Nakayama Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation Cell Reports, 2021-02-09;34(6):108734. 2021-02-09 [PMID: 33567275] (Mouse)
• S Estfanous, K Krause, MNK Anne, M Eltobgy, K Caution, A Abu Khweek, K Hamilton, A Badr, K Daily, C Carafice, D Baetzhold, X Zhang, T Li, H Wen, MA Gavrilin, H Haffez, S Soror, AO Amer Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo Scientific Reports, 2021-01-13;11(1):855. 2021-01-13 [PMID: 33441602] (Mouse)
• J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta EBioMedicine, 2020-09-23;60(0):102984. 2020-09-23 [PMID: 32979835] (Mouse)
• MB Reis, J Elias-Oliv, MR Pastore, SG Ramos, LG Gardinassi, LH Faccioli Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation Toxins (Basel), 2020-03-05;12(3):. 2020-03-05 [PMID: 32150895] (Mouse)
• VS Tapia, MJD Daniels, P Palazón-Ri, M Dewhurst, NM Luheshi, J Rivers-Aut, J Green, E Redondo-Ca, P Kaldis, G Lopez-Cast, D Brough The three cytokines IL-1?, IL-18, and IL-1? share related but distinct secretory routes J. Biol. Chem., 2019-04-02;294(21):8325-8335. 2019-04-02 [PMID: 30940725] (Mouse)
• NC Howard, ND Marin, M Ahmed, BA Rosa, J Martin, M Bambouskov, A Sergushich, E Loginichev, N Kurepina, J Rangel-Mor, L Chen, BN Kreiswirth, RS Klein, JM Balada-Lla, JB Torrelles, GK Amarasingh, M Mitreva, MN Artyomov, FF Hsu, B Mathema, SA Khader Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes Nat Microbiol, 2018-09-17;0(0):. 2018-09-17 [PMID: 30224802] (Mouse)
• K Hirai, H Furusho, K Hirota, H Sasaki Activation of hypoxia-inducible factor�1 attenuates periapical inflammation and bone loss Int J Oral Sci, 2018-04-13;10(2):12. 2018-04-13 [PMID: 29654284] (Mouse)
• T Karasawa, A Kawashima, F Usui-Kawan, S Watanabe, H Kimura, R Kamata, K Shirasuna, Y Koyama, A Sato-Tomit, T Matsuzaka, H Tomoda, SY Park, N Shibayama, H Shimano, T Kasahara, M Takahashi Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages Arterioscler. Thromb. Vasc. Biol., 2018-02-08;0(0):. 2018-02-08 [PMID: 29437575] (Mouse)
• B Lagrange, S Benaoudia, P Wallet, F Magnotti, A Provost, F Michal, A Martin, F Di Lorenzo, BF Py, A Molinaro, T Henry Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 Nat Commun, 2018-01-16;9(1):242. 2018-01-16 [PMID: 29339744] (Mouse)
• MJD Daniels, AD Adamson, N Humphreys, D Brough CRISPR/Cas9 mediated mutation of mouse IL-1? nuclear localisation sequence abolishes expression Sci Rep, 2017-12-06;7(1):17077. 2017-12-06 [PMID: 29213066] (Mouse)
• Caspase-2 deficiency accelerates chemically induced liver cancer in mice Cell Death Differ, 2016-08-12;0(0):. 2016-08-12 [PMID: 27518436] (Mouse)
• Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor Sci Rep, 2016-05-24;6(0):26490. 2016-05-24 [PMID: 27215684] (Mouse)
• A Savers, O Rasid, M Parlato, M Brock, G Jouvion, B Ryffel, JM Cavaillon, G Eberl, O Ibrahim-Gr Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge PLoS ONE, 2016-04-14;11(4):e0153829. 2016-04-14 [PMID: 27078879] (Mouse)
• Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol, 2015-07-27;195(5):2365-73. 2015-07-27 [PMID: 26216893] (Mouse)
• Coll R, Robertson A, Chae J, Higgins S, Munoz-Planillo R, Inserra M, Vetter I, Dungan L, Monks B, Stutz A, Croker D, Butler M, Haneklaus M, Sutton C, Nunez G, Latz E, Kastner D, Mills K, Masters S, Schroder K, Cooper M, O'Neill L A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med, 2015-02-16;21(3):248-55. 2015-02-16 [PMID: 25686105] (Mouse)
• Ainscough J, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman R Dendritic cell IL-1alpha and IL-1beta are polyubiquitinated and degraded by the proteasome. J Biol Chem, 2014-11-04;289(51):35582-92. 2014-11-04 [PMID: 25371210] (Mouse)
• Jain , Ruchi, Kazmierczak , Barbara A conservative amino acid mutation in the master regulator FleQ renders Pseudomonas aeruginosa aflagellate. PLoS ONE, 2014-05-14;9(5):e97439. 2014-05-14 [PMID: 24827992] (Mouse)
• Walsh K, Teijaro J, Brock L, Fremgen D, Collins P, Rosen H, Oldstone M Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. J Virol, 2014-03-26;88(11):6281-93. 2014-03-26 [PMID: 24672024] (Mouse)
• Murphy A, O'Keeffe K, Lalor S, Maher B, Mills K, McLoughlin R Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J Immunol, 2014-03-12;192(8):3697-708. 2014-03-12 [PMID: 24623128] (Mouse)
• Dong X, Liu Y, Chang X, Lei L, Zhong G Signaling via tumor necrosis factor receptor 1 but not Toll-like receptor 2 contributes significantly to hydrosalpinx development following Chlamydia muridarum infection. Infect Immun, 2014-02-18;82(5):1833-9. 2014-02-18 [PMID: 24549331] (Mouse)
• Bello-Irizarry S, Wang J, Johnston C, Gigliotti F, Wright T MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection. J Immunol, 2013-11-29;192(1):282-92. 2013-11-29 [PMID: 24293628] (Mouse)
• Horton J, Hudak K, Chung E, White A, Scroggins B, Burkeen J, Citrin D Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation. Stem Cells, 2013-10-01;31(10):2231-41. 2013-10-01 [PMID: 23897677] (Mouse)
• Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell, 2011-09-16;146(6):980-91. 2011-09-16 [PMID: 21925319] (Mouse)
• Barber DL, Mayer-Barber KD, Feng CG CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. J. Immunol., 2010-12-20;186(3):1598-607. 2010-12-20 [PMID: 21172867] (Mouse)
• Tarabishy AB, Aldabagh B, Sun Y, Imamura Y, Mukherjee PK, Lass JH, Ghannoum MA, Pearlman E MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J. Immunol., 2008-07-01;181(1):593-600. 2008-07-01 [PMID: 18566426] (Mouse)
• Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J. Immunol., 2008-03-15;180(6):4022-31. 2008-03-15 [PMID: 18322211] (Mouse)
• Cheng W, Shivshankar P, Li Z, Chen L, Yeh IT, Zhong G Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect. Immun., 2007-11-19;76(2):515-22. 2007-11-19 [PMID: 18025098] (Mouse)
• Robertson SA, Care AS, Skinner RJ Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol. Reprod., 2007-01-10;76(5):738-48. 2007-01-10 [PMID: 17215490] (Mouse)
• Robertson SA, Skinner RJ, Care AS Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J. Immunol., 2006-10-01;177(7):4888-96. 2006-10-01 [PMID: 16982931] (Mouse)

Bioinformatics

• Gene Symbol: Il1a