Mouse GDF-15 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse GDF-15 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Gdf15

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse GDF-15 DuoSet ELISA, 15 Plate

• GDF15
• GDF-15
• growth differentiation factor 15
• growth/differentiation factor 15
• Macrophage inhibitory cytokine 1
• MIC-1
• MIC-1NSAID-activated gene 1 protein
• MIC1Prostate differentiation factor
• NAG-1
• NAG-1NSAID-regulated gene 1 protein
• NSAID (nonsteroidal inflammatory drug)-activated protein 1
• PDF
• PDFGDF-15
• PLAB
• PLABNRG-1
• Placental bone morphogenetic protein
• Placental TGF-beta
• PTGF-beta
• PTGFBPTGF-beta

Background

Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.

Publications for GDF-15 (DY6385)(10)

Publications using DY6385

• L'homme, L;Sermikli, BP;Haas, JT;Fleury, S;Quemener, S;Guinot, V;Barreby, E;Esser, N;Caiazzo, R;Verkindt, H;Legendre, B;Raverdy, V;Cheval, L;Paquot, N;Piette, J;Legrand-Poels, S;Aouadi, M;Pattou, F;Staels, B;Dombrowicz, D; Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH Nature communications 2024-08-21 [PMID: 39169003] (Mouse)
• Kincaid, JWR;Rimmington, D;Tadross, JA;Cimino, I;Zvetkova, I;Kaser, A;Richards, P;Patel, S;O'Rahilly, S;Coll, AP; The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15 Scientific reports 2024-01-22 [PMID: 38253650] (Mouse)
• Reyes, J;Zhao, Y;Pandya, K;Yap, GS; Growth differentiation factor-15 is an IFN-? regulated mediator of infection-induced weight loss and the hepatic FGF21 response Brain, behavior, and immunity 2023-11-26 [PMID: 38013040] (Mouse)
• Xiao, S;Li, VL;Lyu, X;Chen, X;Wei, W;Abbasi, F;Knowles, JW;Deng, S;Tiwari, G;Shi, X;Zheng, S;Farrell, L;Chen, ZZ;Taylor, KD;Guo, X;Goodarzi, MO;Wood, AC;Chen, YI;Lange, LA;Rich, SS;Rotter, JI;Clish, CB;Tahir, UA;Gerszten, RE;Benson, MD;Long, JZ; Lac-Phe mediates the anti-obesity effect of metformin bioRxiv : the preprint server for biology 2023-11-04 [PMID: 37961394] (Mouse)
• A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Mouse)
• B Chelette, CL Chidomere, R Dantzer The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice Brain, Behavior, and Immunity, 2022-11-24;108(0):45-54. 2022-11-24 [PMID: 36427806] (Mouse)
• S Patel, A Haider, A Alvarez-Gu, G Bidault, JS El-Sayed M, E Guiu-Jurad, JA Tadross, J Warner, J Harrison, S Virtue, F Scurria, I Zvetkova, M Blüher, KS Small, S O'Rahilly, DB Savage Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice Molecular Metabolism, 2022-09-02;65(0):101589. 2022-09-02 [PMID: 36064109] (Mouse)
• L Mulderrig, JI Garaycoech, ZK Tuong, CL Millington, FA Dingler, JR Ferdinand, L Gaul, JA Tadross, MJ Arends, S O'Rahilly, GP Crossan, MR Clatworthy, KJ Patel Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response Nature, 2021-11-24;600(7887):158-163. 2021-11-24 [PMID: 34819667] (Mouse)
• J Varghese, JV James, R Anand, M Narayanasa, G Rebekah, B Ramakrishn, AJ Nellickal, M Jacob Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet J. Nutr. Biochem., 2020-06-02;84(0):108441. 2020-06-02 [PMID: 32629238] (Mouse)
• KH Kim, SH Kim, DH Han, YS Jo, YH Lee, MS Lee Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice Sci Rep, 2018-05-01;8(1):6789. 2018-05-01 [PMID: 29717162] (Mouse)

Bioinformatics

• Gene Symbol: Gdf15