Mouse Gas6 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Gas6 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Gas6

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Gas6 DuoSet ELISA, 15 Plate

• AXLLG
• AXLLGAXL stimulatory factor
• AXSFAXL receptor tyrosine kinase ligand
• DKFZp666G247
• FLJ34709
• Gas6
• GAS-6
• growth arrest-specific 6
• growth arrest-specific protein 6

Background

Gas6 (Growth Arrest Specific 6) is a secreted protein that contains an extensively gamma-carboxylated N-terminal Gla domain and is dependent upon vitamin K for activity. Gas6 signals through the receptors Axl, Dtk/Tyro3, and Mer and is inhibited by shed soluble forms of Axl and Mer. Gas6 protects cells from stress-induced apoptosis and promotes phagocytosis of apoptotic cell debris, promotes platelet activation but inhibits inflammatory cytokine production, and inhibits VEGF-induced angiogenesis, and regulates tumor cell invasiveness.

Publications for Gas6 (DY986)(14)

Publications using DY986

• Liu, Q;Niu, Y;Pei, Z;Yang, Y;Xie, Y;Wang, M;Wang, J;Wu, M;Zheng, J;Yang, P;Hao, H;Pang, Y;Bao, L;Dai, Y;Niu, Y;Zhang, R; Gas6-Axl signal promotes indoor VOCs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk Journal of hazardous materials 2024-05-31 [PMID: 38824778] (Mouse)
• Aydin, N;Ouliass, B;Ferland, G;Hafizi, S; Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle Cells 2024-05-18 [PMID: 38786095] (Mouse)
• Di Carlo, SE;Raffenne, J;Varet, H;Ode, A;Granados, DC;Stein, M;Legendre, R;Tuckermann, J;Bousquet, C;Peduto, L; Depletion of slow-cycling PDGFR?+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis Nature immunology 2023-10-05 [PMID: 37798557] (Mouse)
• Neus Martínez-Bosch, Helena Cristóbal, Mar Iglesias, Meritxell Gironella, Luis Barranco, Laura Visa et al. Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis eBioMedicine 2022-01-01 [PMID: 34973624] (Mouse)
• J Bordoloi, D Ozah, T Bora, J Kalita, P Manna Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPAR? signaling cascade of lipid metabolism J. Nutr. Biochem., 2019-05-25;70(0):174-184. 2019-05-25 [PMID: 31226525] (Mouse)
• PY Dumas, C Naudin, S Martin-Lan, B Izac, L Casetti, O Mansier, B Rousseau, A Artus, M Dufossée, A Giese, P Dubus, A Pigneux, V Praloran, A Bidet, A Villacrece, AV Guitart, N Milpied, O Kosmider, I Vigon, V Desplat, I Dusanter-F, JM Pasquet Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL Haematologica, 2019-03-28;0(0):. 2019-03-28 [PMID: 30923103] (Mouse)
• Y Chen, J Wang, X Chen, D Li, X Han Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels Aquat. Toxicol., 2018-03-17;199(0):116-126. 2018-03-17 [PMID: 29621671] (Mouse)
• A Decker, Y Jung, FC Cackowski, K Yumoto, J Wang, RS Taichman Sympathetic signaling reactivates quiescent�disseminated prostate cancer cells in the bone marrow Mol. Cancer Res., 2017-08-16;0(0):. 2017-08-16 [PMID: 28814453] (Mouse)
• M Kurowska-S, S Alivernini, EG Melchor, A Elmesmari, B Tolusso, C Tange, L Petricca, DS Gilchrist, G Di Sante, C Keijzer, L Stewart, C Di Mario, V Morrison, JM Brewer, D Porter, S Milling, RD Baxter, D McCarey, E Gremese, G Lemke, G Ferracciol, C McSharry, IB McInnes MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis Nat Commun, 2017-06-22;8(0):15877. 2017-06-22 [PMID: 28639625] (Mouse)
• Axl is required for TGF-?2-induced dormancy of prostate cancer cells in the bone marrow Sci Rep, 2016-11-07;6(0):36520. 2016-11-07 [PMID: 27819283] (Mouse)
• Zagorska A, Traves P, Lew E, Dransfield I, Lemke G Diversification of TAM receptor tyrosine kinase function. Nat Immunol, 2014-09-07;15(10):920-8. 2014-09-07 [PMID: 25194421] (Mouse)
• Deng T, Zhang Y, Chen Q, Yan K, Han D Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages. Immunology, 2012-01-01;135(1):40-50. 2012-01-01 [PMID: 22043818] (Mouse)
• Anwar A, Keating AK, Joung D, Sather S, Kim GK, Sawczyn KK, Brandao L, Henson PM, Graham DK Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress. J. Leukoc. Biol., 2009-04-22;86(1):73-9. 2009-04-22 [PMID: 19386698] (Mouse)
• Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, Garcia de Frutos P, Dahlback B, Carmeliet P, Hoylaerts MF, Moons L Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood, 2007-12-21;111(8):4096-105. 2007-12-21 [PMID: 18156494] (Mouse)

FAQs for Gas6 (DY986). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Gas6