Mouse C-Reactive Protein/CRP Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse C-Reactive Protein/CRP Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse C-Reactive Protein/CRP immunoassay is a 4.5 hour solid-phase ELISA designed to measure CRP in mouse cell culture supernates, tissue lysates, serum, and plasma. It contains NS0-expressed recombinant mouse CRP and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse CRP. Results obtained using natu...ral mouse CRP showed dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse CRP.
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• Specificity: Natural and recombinant mouse CRP.
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Crp

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse C-Reactive Protein/CRP Quantikine ELISA Kit

• C-Reactive Protein
• C-reactive protein, pentraxin-related
• CRP
• MGC88244
• pentraxin 1
• PTX1MGC149895

Background

C-Reactive Protein (CRP), also known as Pentraxin 1, is a secreted pentameric protein that functions as a sensor and activator for the innate immune response. In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation. In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2. CRP binds, opsonizes, and induces the phagocytosis of bacteria and apoptotic cells. It regulates activation of the classical complement pathway by binding several proteins in the complement cascade as well as Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells. It also promotes dendritic cell maturation and humoral immunity. In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in myocardial infarction, and inhibits the repair of injured vascular endothelium.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for C-Reactive Protein/CRP (MCRP00)(13)

Publications using MCRP00

• E Palathinga, J George, M Tarique, S Iyer, P Sahay, B Gomez Agui, DB Edwards, B Giri, V Sethi, T Jain, P Sharma, U Vaish, HK C Jacob, A Ferrantell, CL Maynard, AK Saluja, RK Dawra, V Dudeja Pirfenidone increases IL10 and improves acute pancreatitis in multiple clinically relevant murine models JCI Insight, 2021;0(0):. 2021 [PMID: 34847076] (Mouse)
• Z Zhang, H Na, Q Gan, Q Tao, Y Alekseyev, J Hu, Z Yan, JB Yang, H Tian, S Zhu, Q Li, IM Rajab, JK Blusztajn, B Wolozin, A Emili, X Zhang, T Stein, LA Potempa, WQ Qiu Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging Cell, 2021;0(0):e13501. 2021 [PMID: 34687487] (Mouse)
• K Claesen, L Roth, JC Mertens, K Hermans, Y Sim, D Hendriks Pleiotropic Effects of Atorvastatin Result in a Downregulation of the Carboxypeptidase U System (CPU, TAFIa, CPB2) in a Mouse Model of Advanced Atherosclerosis Pharmaceutics, 2021;13(10):. 2021 [PMID: 34684024] (Mouse)
• X Liu, Y Xiao, Q Zhu, Y Cui, H Hao, M Wang, PJ Cowan, RJ Korthuis, G Li, Q Sun, Z Liu Circulating Endothelial Progenitor Cells Are Preserved in Female Mice Exposed to Ambient Fine Particulate Matter Independent of Estrogen International Journal of Molecular Sciences, 2021;22(13):. 2021 [PMID: 34281260] (Mouse)
• JK Nam, AR Kim, SH Choi, JH Kim, KJ Choi, S Cho, JW Lee, HJ Cho, YW Kwon, J Cho, KS Kim, J Kim, HJ Lee, TS Lee, S Bae, HJ Hong, YJ Lee An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage Nature Communications, 2021;12(1):3279. 2021 [PMID: 34078883] (Mouse)
• T Yasuda, M Koiwa, A Yonemura, K Miyake, R Kariya, S Kubota, T Yokomizo-N, N Yasuda-Yos, T Uchihara, R Itoyama, L Bu, L Fu, K Arima, D Izumi, S Iwagami, K Eto, M Iwatsuki, Y Baba, N Yoshida, H Ohguchi, S Okada, K Matsusaki, G Sashida, A Takahashi, P Tan, H Baba, T Ishimoto Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination Cell Reports, 2021;34(8):108779. 2021 [PMID: 33626356] (Mouse)
• Y Yoon, G Kim, MG Noh, JH Park, M Jang, S Fang, H Park Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity Exp. Mol. Med., 2020;0(0):. 2020 [PMID: 32917958] (Mouse)
• J Varghese, JV James, R Anand, M Narayanasa, G Rebekah, B Ramakrishn, AJ Nellickal, M Jacob Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet J. Nutr. Biochem., 2020;84(0):108441. 2020 [PMID: 32629238] (Mouse)
• S Yeo, H Park, E Seo, J Kim, BK Kim, IS Choi, CS Huh Anti-Inflammatory and Gut Microbiota Modulatory Effect of Lactobacillus rhamnosus Strain LDTM 7511 in a Dextran Sulfate Sodium-Induced Colitis Murine Model Microorganisms, 2020;8(6):. 2020 [PMID: 32512895] (Mouse)
• NO McPherson, M Lane Metformin treatment of high-fat diet-fed obese male mice restores sperm function and fetal growth, without requiring weight loss Asian J. Androl., 2020;0(0):. 2020 [PMID: 32098932] (Mouse)
• C Liang, J Li, C Lu, D Xie, J Liu, C Zhong, X Wu, R Dai, H Zhang, D Guan, B Guo, B He, F Li, X He, W Zhang, BT Zhang, G Zhang, A Lu HIF1alpha inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis Nat Commun, 2019;10(1):4579. 2019 [PMID: 31594926] (Mouse)
• DK Lee, JH Kim, J Kim, S Choi, M Park, W Park, S Kim, KS Lee, T Kim, J Jung, YK Choi, KS Ha, MH Won, TR Billiar, YG Kwon, YM Kim REDD-1 aggravates endotoxin-induced inflammation via atypical NF-?B activation FASEB J., 2018;0(0):fj201701436R. 2018 [PMID: 29547704] (Mouse)
• L Wang, H Ma, Y Xue, H Shi, T Ma, X Cui Berberine inhibits the ischemia-reperfusion injury induced inflammatory response and apoptosis of myocardial cells through the phosphoinositide 3-kinase/RAC-? serine/threonine-protein kinase and nuclear factor-?B signaling pathways Exp Ther Med, 2018;15(2):1225-1232. 2018 [PMID: 29403554] (Mouse)

Bioinformatics

• Gene Symbol: Crp