Mouse C-Reactive Protein/CRP DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse C-Reactive Protein/CRP DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Crp

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse C-Reactive Protein/CRP DuoSet ELISA, 15 Plate

• C-Reactive Protein
• C-reactive protein, pentraxin-related
• CRP
• MGC88244
• pentraxin 1
• PTX1MGC149895

Background

C-Reactive Protein (CRP), also known as Pentraxin 1, is a secreted pentameric protein that functions as a sensor and activator for the innate immune response. In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation. In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2. CRP binds, opsonizes, and induces the phagocytosis of bacteria and apoptotic cells. It regulates activation of the classical complement pathway by binding several proteins in the complement cascade as well as Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells. It also promotes dendritic cell maturation and humoral immunity. In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in myocardial infarction, and inhibits the repair of injured vascular endothelium.

Publications for C-Reactive Protein/CRP (DY1829)(9)

Publications using DY1829

• Nicola, T;Wenger, N;Xu, X;Evans, M;Qiao, L;Rezonzew, G;Yang, Y;Jilling, T;Margaroli, C;Genschmer, K;Willis, K;Ambalavanan, N;Blalock, JE;Gaggar, A;Lal, CV; A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation Nature communications 2024-08-19 [PMID: 39160214] (Mouse)
• Thiel, FG;Asgarbeik, S;Glaubitz, J;Wilden, A;Lerch, MM;Weiss, FU;Sendler, M; IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis Scientific reports 2023-07-04 [PMID: 37402858] (Mouse, Transgenic Mouse)
• NM Wenger, L Qiao, T Nicola, Z Nizami, X Xu, KA Willis, N Ambalavana, A Gaggar, CV Lal Efficacy of a Probiotic and Herbal Supplement in Models of Lung Inflammation Microorganisms, 2022-10-28;10(11):. 2022-10-28 [PMID: 36363728] (Mouse)
• A Vorobyev, Y Gupta, T Sezin, H Koga, YC Bartsch, M Belheouane, S Künzel, C Sina, P Schilf, H Körber-Ahr, F Beltsiou, A Lara Ernst, S Khil'chenk, H Al-Aasam, RA Manz, S Diehl, M Steinhaus, J Jascholt, P Kouki, WH Boehncke, TN Mayadas, D Zillikens, CD Sadik, H Nishi, M Ehlers, S Möller, K Bieber, JF Baines, SM Ibrahim, RJ Ludwig Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line Nat Commun, 2019-09-10;10(1):4097. 2019-09-10 [PMID: 31506438] (Mouse)
• S Al-Salam, S Hashmi Myocardial Ischemia Reperfusion Injury: Apoptotic, Inflammatory and Oxidative Stress Role of Galectin-3 Cell. Physiol. Biochem., 2018-10-24;50(3):1123-1139. 2018-10-24 [PMID: 30355930] (Mouse)
• BS Chae Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators Toxicol Res, 2018-01-15;34(1):65-73. 2018-01-15 [PMID: 29372003] (Mouse)
• HW Tseng, TT Glant, MA Brown, TJ Kenna, GP Thomas, AR Pettit Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis BMC Musculoskelet Disord, 2017-05-30;18(1):228. 2017-05-30 [PMID: 28558827] (Mouse)
• JM Florence, A Krupa, LM Booshehri, TC Allen, AK Kurdowska Metalloproteinase-9 contributes to endothelial dysfunction in atherosclerosis via protease activated receptor-1 PLoS ONE, 2017-02-06;12(2):e0171427. 2017-02-06 [PMID: 28166283] (Mouse)
• Habibzay , M, Saldana , J I, Goulding , J, Lloyd , C M, Hussell , T Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol, 2012-05-02;5(5):524-34. 2012-05-02 [PMID: 22549744] (Mouse)

Bioinformatics

• Gene Symbol: Crp