MMRN2 Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: MMRN2 Antibody [NBP1-83977] - Staining of human cell line U-2 OS shows localization to vesicles. Antibody staining is shown in green.

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] - Staining of human placenta shows strong cytoplasmic positivity in endothelial cells.

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] - Staining of human testis shows strong cytoplasmic positivity in endothelial cells and nuclear positivity in cells in seminiferous ducts.

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] - Staining of human colon shows strong cytoplasmic positivity in endothelial cells.

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] - Staining of human liver shows weak cytoplasmic positivity in endothelial cells and no positivity in hepatocytes.

• Reactivity: Hu
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

MMRN2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEK
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MMRN2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  MMRN2 Protein (NBP1-83977PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for MMRN2 Antibody - BSA Free

• Elastin microfibril interface located protein 3
• Elastin microfibril interfacer 3EMILIN-3
• EMILIN3
• EMILIN-like protein EndoGlyx-1
• EndoGlyx-1 p125/p140 subunit
• Endoglyx-1
• FLJ13465
• MMRN2
• multimerin 2
• multimerin-2

Background

The MMRN2 gene encodes a 949 amino acid long, 104 kDA multimerin-2 protein that prevents endothelial cells motility. The elastic microfibril interface-located (EMILIN) protein family is an extracellular matrix glycoprotein. Additionally, this protein acts as a negative regulator of angiogenesis by downregulating activation by binding VEGFA. MMRN2 has been linked to adenocarcinoma and skin cancer as it participates in MAPK signaling, PTEN pathway, transendothelial migration of leukocytes, and UPA-UPAR pathway. It has been known to interact with genes VDR, MAPK7, MAP3K3, and DAXX.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MMRN2