MLX Antibody (PCRP-MLX-1G8) [DyLight 350]

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF, MA
• Clone: PCRP-MLX-1G8
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 350

MLX Antibody (PCRP-MLX-1G8) [DyLight 350] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Recombinant full-length human MLX protein (Uniprot: Q9UH92)
• Localization: Nucleus and cytoplasm.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: MLX
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Protein Array
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP3-08241. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for MLX Antibody (PCRP-MLX-1G8) [DyLight 350]

• BHLHD13
• bHLHd13Max-like bHLHZip protein
• BigMax alpha
• BigMax protein
• Class D basic helix-loop-helix protein 13
• MAD7
• MAX-like protein X
• MLX
• MXD7
• TCFL4
• TCFL4Protein BigMax
• transcription factor-like 4
• Transcription factor-like protein 4

Background

Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MLX