Species: Hu
Applications: WB, ICC
Host: Goat Polyclonal
Species: Hu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA
Species: Hu
Applications: WB, ELISA, PA
Species: Hu
Applications: AC
Species: Hu
Applications: RNAi, RNAi SP
Species: Hu
Applications: RNAi, RNAi SP
Species: Hu
Applications: RNAi, RNAi SP
Description
Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
6945 |
| Alternate Names |
- BHLHD13
- transcription factor-like 4
- BigMax protein
- MXD7
- Transcription factor-like protein 4
- MAD7
- TCFL4Protein BigMax
- bHLHd13Max-like bHLHZip protein
- Class D basic helix-loop-helix protein 13
- MAX-like protein X
|
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-Western Blot-NBP2-05216-img0001.jpg)
