MLX Products

Description

Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.

Bioinformatics

Entrez	6945 Human 21428 Mouse 360631 Rat
Uniprot	AAH10689 Human NM_198204 Human NP_733752 Human NP_733752.1 Human Q9UH92 Human NP_937848.1 Human
Product By Gene ID	6945
Alternate Names	BHLHD13 transcription factor-like 4 BigMax protein MXD7 Transcription factor-like protein 4 MAD7 TCFL4Protein BigMax bHLHd13Max-like bHLHZip protein Class D basic helix-loop-helix protein 13 MAX-like protein X

Diseases related to MLX

Discover more about diseases related to MLX.

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Liver Carcinoma
Maturity Onset Diabetes Mellitus In Young
Liver Neoplasms
Malignant Neoplasms
Hepatitis
Neoplasms
Hyperglycemia
Obesity
Carcinoma
Hepatitis B
Hypoxia
Hepatoblastoma
Insulin Resistance
Hemorrhage
Liver Neoplasms, Experimental
Diabetes Mellitus, Insulin-dependent
Bleeding Tendency

Pathways for MLX

View related products by pathway and learn more about each of the pathways below.

Secretion
Insulin Secretion
Coagulation
Localization
Translation
Blood Coagulation
Cholesterol Homeostasis
Hepatocyte Differentiation
Gluconeogenesis
Glucose Homeostasis
Pathogenesis
Glycolysis
Liver Development
Cell Growth
Transport
Regulation Of Gene Expression
Cell Cycle
Cell Death
Viral Replication
Cell Differentiation

PTMs for MLX

Learn more about PTMs related to MLX.

Phosphorylation
Oxidation
Carboxylation
Acetylation
Methylation
Nitrosylation
Hydroxylation
Cleavage
Glycosylation
Ubiquitination

Bioinformatics Tool for MLX

Discover related pathways, diseases and genes to MLX. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related MLX Blog Posts

Check out the latest blog posts on MLX.

ChREBP, a glucose sensitive transcription factor with role in glucose-lipids homeostasis and cancer ChREBP (carbohydrate response element-binding protein) is a glucose responsive basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that binds MLX and then carbohydrate response element /ChoRE for the induction of genes involved in...    Read more.

Read more MLX related blogs.