MLX Products

Antibodies
MLX Antibody
MLX Antibody
AF4186
Species: Hu
Applications: WB, ICC
Host: Goat Polyclonal
MLX Antibody
MLX Antibody
NBP1-46146
Species: Hu
Applications: IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
MLX Antibody
MLX Antibody
NB100-92408
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
MLX Overexpression Lysate (De ...
MLX Overexpression Lysate (Denatured)
H00006945-T02
Species: Hu
Applications: WB
MLX Overexpression Lysate (Na ...
MLX Overexpression Lysate (Native)
NBP2-05216
Applications: WB
MLX Overexpression Lysate (Na ...
MLX Overexpression Lysate (Native)
NBP2-10013
Applications: WB
Proteins
MLX Partial Recombinant Prote ...
MLX Partial Recombinant Protein
H00006945-Q01
Species: Hu
Applications: WB, ELISA, PA
MLX Recombinant Protein
MLX Recombinant Protein
H00006945-P02
Species: Hu
Applications: WB, ELISA, PA
MLX Recombinant Protein Antig ...
MLX Recombinant Protein Antigen
NBP2-37937PEP
Species: Hu
Applications: AC
RNAi
MLX RNAi
MLX RNAi
H00006945-R01
Species: Hu
MLX RNAi
MLX RNAi
H00006945-R03
Species: Hu
MLX RNAi
MLX RNAi
H00006945-R02
Species: Hu

Description

Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 6945
Alternate Names
  • BHLHD13
  • transcription factor-like 4
  • BigMax protein
  • MXD7
  • Transcription factor-like protein 4
  • MAD7
  • TCFL4Protein BigMax
  • bHLHd13Max-like bHLHZip protein
  • Class D basic helix-loop-helix protein 13
  • MAX-like protein X

Bioinformatics Tool for MLX

Discover related pathways, diseases and genes to MLX. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MLX Blog Posts

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ChREBP (carbohydrate response element-binding protein) is a glucose responsive basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that binds MLX and then carbohydrate response element /ChoRE for the induction of genes involved in...    Read more.
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