Mkl1 Antibody

Product Discontinued

Mkl1 Antibody Summary

• Immunogen: The immunogen for this product maps to a region between residue 700 and 750 of human megakaryoblastic leukemia (translocation) 1 using the numbering given in entry NP_065882.1 (GeneID 57591).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MRTFA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Mkl1 Antibody

• AMKL
• KIAA1438
• MALSAP and coiled-coil domain
• megakaryoblastic leukemia (translocation) 1
• Megakaryoblastic leukemia 1 protein
• Megakaryocytic acute leukemia protein
• MKL/myocardin-like protein 1
• Myocardin-related transcription factor A
• RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein

Background

Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factor A (MRTF-A), also known as MKL1, interacts with SRF and stimulates its transcriptional activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MRTFA
• Uniprot:
  • NP_065882.1(Human)