Mkl1 Antibody

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Immunohistochemistry: Mkl1 Antibody [NBP1-71949]-FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-MKL1) used at a dilution of 1:250

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-71949
    • Availability
      Product Discontinued

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Mkl1 Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 700 and 750 of human megakaryoblastic leukemia (translocation) 1 using the numbering given in entry NP_065882.1 (GeneID 57591).
Clonality
Polyclonal
Host
Rabbit
Gene
MKL1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:100-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Mkl1 Antibody

  • AMKL
  • KIAA1438
  • MALSAP and coiled-coil domain
  • megakaryoblastic leukemia (translocation) 1
  • Megakaryoblastic leukemia 1 protein
  • Megakaryocytic acute leukemia protein
  • MKL/myocardin-like protein 1
  • Myocardin-related transcription factor A
  • RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein

Background

Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factor A (MRTF-A), also known as MKL1, interacts with SRF and stimulates its transcriptional activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol MKL1
Uniprot