MKK3/MEK3 Antibody (23GB2420)

• Reactivity: Hu, Mu, Rt
• Applications: WB, Flow, ICC/IF, Mycoplasma
• Clone: 23GB2420
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

MKK3/MEK3 Antibody (23GB2420) Summary

• Immunogen: A synthesized peptide derived from human MKK3/MEK3 (Uniprot: P46734)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MAP2K3
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Knockdown Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for MKK3/MEK3 Antibody (23GB2420)

• MAP kinase kinase 3
• MAP2K3
• MAPK/ERK kinase 3
• MAPKK 3
• MAPKK3PRKMK3dual specificity mitogen-activated protein kinase kinase 3
• MEK3
• MEK3MEK 3
• mitogen activated protein kinase kinase 3
• mitogen-activated protein kinase kinase 3
• MKK3
• MKK3EC 2.7.12.2
• PRKMK3

Background

Mitogen-acitvated protein kinase kinase 3 (MKK3) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK3, closely related to MKK6, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MKK3 is activated by mitogenic and environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter and participates in the MAP kinase- mediated signaling cascade (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAP2K3