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HAF007). For additional reference, recombinant human MKK3 and MKK6 (2 ng/lane) were included. A specific band for MKK3 was detected at approximately 40 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm and nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox" target="_blank">
Mitogen-acitvated protein kinase kinase 3 (MKK3) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK3, closely related to MKK6, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MKK3 is activated by mitogenic and environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter and participates in the MAP kinase- mediated signaling cascade (4).
![Western Blot MKK3/MEK3 Antibody (275909) [Unconjugated]](http://images.novusbio.com/images/antibody/MKK3_MAB2515_Western_Blot_6037.jpg)
![Western Blot MKK3/MEK3 [p Ser189] Antibody - BSA Free](http://images.novusbio.com/fullsize/MKK3-MEK3-[p-Ser189]-Antibody-Western-Blot-NB100-82048-img0009.jpg)
![Immunocytochemistry MKK3/MEK3 Antibody (275909) [Unconjugated]](http://images.novusbio.com/images/antibody/MKK3_MAB2515_Immunocytochemistry__Immunofluorescence_19366.jpg)
![Immunocytochemistry/ Immunofluorescence MKK3/MEK3 [p Ser189] Antibody - BSA Free](http://images.novusbio.com/fullsize/MKK3-MEK3-[p-Ser189]-Antibody-Immunocytochemistry-Immunofluorescence-NB100-82048-img0005.jpg)
![Western Blot MKK3/MEK3 [p Ser189] Antibody - BSA Free](http://images.novusbio.com/fullsize/MKK3-MEK3-[p-Ser189]-Antibody-Western-Blot-NB100-82048-img0007.jpg)
![Immunohistochemistry-Paraffin MKK3/MEK3 [p Ser189] Antibody - BSA Free](http://images.novusbio.com/fullsize/nb100-82048_rabbit-polyclonal-mkk3-mek3-p-ser189-antibody-103202523464532.jpg)
