MKK3/MEK3 Products

Description

Mitogen-acitvated protein kinase kinase 3 (MKK3) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK3, closely related to MKK6, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MKK3 is activated by mitogenic and environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter and participates in the MAP kinase- mediated signaling cascade (4).

Bioinformatics

Entrez	26397 Mouse 303200 Rat 5606 Human
Uniprot	AAH32478 Human NM_145109 Human NP_002747 Human NP_659731 Human NP_659731.1 Human P36507 Human P46734 Human P46734-2 Human
Product By Gene ID	5606
Alternate Names	MAP kinase kinase 3 MAPK/ERK kinase 3 MAPKK 3 MAPKK3PRKMK3dual specificity mitogen-activated protein kinase kinase 3 MEK3MEK 3 mitogen activated protein kinase kinase 3 mitogen-activated protein kinase kinase 3 MKK3EC 2.7.12.2

Research Areas for MKK3/MEK3

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Hypoxia
Lipid and Metabolism
Phospho-Specific
Protein Kinase