Mind Bomb 1/MIB1 Antibody [mFluor Violet 500 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: mFluor Violet 500 SE

Mind Bomb 1/MIB1 Antibody [mFluor Violet 500 SE] Summary

• Immunogen: MIB1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human MIB1. The immunogen is located within amino acids 920 - 970 of MIB1. Amino Acid Squence: IPVLQKDKDNTNVNADVQK
• Specificity: Mind Bomb 1/MIB1 antibody is human, mouse and rat reactive. At least three isoforms of Mind Bomb 1/MIB1 are known to exist.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MIB1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Mind Bomb 1/MIB1 Antibody [mFluor Violet 500 SE]

• DAPK-interacting protein 1
• DIP1
• DIP-1FLJ90676
• DKFZp686I0769
• DKFZp761M1710
• E3 ubiquitin-protein ligase MIB1
• EC 6.3.2
• EC 6.3.2.-
• KIAA1323
• MGC129660
• MIB
• MIB1
• Mind Bomb 1
• Mind bomb homolog 1
• mindbomb homolog 1 (Drosophila)
• ubiquitin ligase mind bomb
• ubiquitin ligase protein MIB1
• Zinc finger ZZ type with ankyrin repeat domain protein 2
• ZZANK2
• ZZANK2MGC129659
• ZZZ6

Background

E3 ubiquitin ligase protein mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. It positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MIB1