NB100-64952 recognizes a polymorphic determinant on the murine MHC (major histocompatibility complex) class I molecule. In the mouse, the MHC class I molecule is expressed on the cell surface of all nucleated cells but expression levels may differ according to cell type. Clone ER-MP52 specifically recognizes mouse strains with the haplotypes H-2b,w16 and H-2d,p,q. Mouse strains with the haplotypes H-2f,r,s,w17,w23,w27 show weak reactivity with this antibody.
Protein G purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.09% Sodium Azide
Protein G purified
Alternate Names for MHC Class I Antibody (ER-HR52) - BSA Free
HLA class I histocompatibility antigen, alpha chain E
HLA class I histocompatibility antigen, E alpha chain
major histocompatibility complex, class I, E
MHC class I antigen E
MHC HLA-E alpha-1
MHC HLA-E alpha-2.1
MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Torrente D, Su E, Schielke G et al. Tissue Plasminogen Activator Interaction with NMDAR1 Promotes Dopaminergic Neuron Degeneration in a Model of A-Synuclein-Mediated Neurotoxicity SSRN Electronic Journal Mar 22 2022
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MHC Class I and the Herpes Simplex Virus MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens. These molecules are highly polymorphic, meaning that they exist in multiple varian... Read full blog post.
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