MHC Class I Products

Antibodies
Antibody Pairs
MHC Class I Antibody Pair
MHC Class I Antibody Pair
H00003133-PW1
Species: Hu
Applications: WB, IP
Lysates
MHC Class I Overexpression Ly ...
MHC Class I Overexpression Lysate ...
H00003133-T01
Species: Hu
Applications: WB
RNAi
MHC Class I RNAi
MHC Class I RNAi
H00003133-R02
Species: Hu

Description

The antigenic agglomerate major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8-positive T cells. It is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (1). Recently shown is a mechanism of antigen acquisition for cross-presentation that couples the antigen presentation system of two adjacent cells and is lost in most tumours: gap-junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen presenting cells for cross-priming (2). The mammalian vomeronasal organ detects social information about gender, status, and individuality. It has been shown that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor-expressing zone of the vomeronasal epithelium (3).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 3133
Alternate Names
  • HLAE
  • MHC
  • MHC HLA-E alpha-2.1
  • EA2.1
  • MHC HLA-E alpha-1
  • EA1.2
  • lymphocyte antigen
  • DKFZp686P19218
  • HLA class I histocompatibility antigen, E alpha chain
  • MHC class I antigen E
  • HLA class I histocompatibility antigen, alpha chain E
  • HLA-6.2
  • QA1
  • major histocompatibility complex, class I, E

Research Areas for MHC Class I

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Major Histocompatibility Complexes

PTMs for MHC Class I

Learn more about PTMs related to MHC Class I.

Phosphorylation
Cleavage
Methylation
Biotinylation
Demethylation
Dephosphorylation
Ribosylation

Bioinformatics Tool for MHC Class I

Discover related pathways, diseases and genes to MHC Class I. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related MHC Class I Blog Posts

Check out the latest blog posts on MHC Class I.
MHC Class I and the Herpes Simplex Virus
MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens.  These molecules are highly polymorphic, meaning that they exist in multiple varian...    Read more.
Major Histocompatibility Complex (MHC) Class I
The products of MHC genes are antigen-presenting molecules (APMs) designed for antigen fragment (peptide) presentation to the T-cell receptor. In particular, MHC Class I molecules play a key role in the immune system by presenting endogenously synthes...    Read more.
Read more MHC Class I related blogs.