mGluR7 Antibody

Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS2694] - Anti-GRM7 / MGLUR7 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

Immunohistochemistry-Paraffin: mGluR7 Antibody [NLS2694] - Analysis of anti-GRM7 / MGLUR7 antibody with human brain, cortex, neurons at dilution 10 ug/ml.

Product Discontinued

mGluR7 Antibody Summary

• Immunogen: Synthetic 15 amino acid peptide from 2nd extracellular domain of human GRM7 / MGLUR7.
• Localization: Cell membrane; Multi-pass membrane protein.
• Specificity: Human mGluR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM8 (67%).
• Predicted Species: Turkey (93%), Chicken (93%), Opossum (93%), Orangutan (100%), Chimpanzee (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRM7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for mGluR7 Antibody

• FLJ40498
• glutamate receptor, metabotropic 7
• GPRC1G
• GRM7
• metabotropic glutamate receptor 7
• MGLU7
• mGluR7
• MGLUR7GPRC1GGLUR7

Background

Metabotropic Glutamate Receptor GRM7 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. GRM7 is highly concentrated at presynaptic terminals and is thought to play an important role in the modulation of glutamatergic synaptic transmission by effecting presynaptic inhibition of glutamate release. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors, which are linked to inhibition of the cyclic AMP signaling cascade. Five mRNA variants of GRM7 have been described; most of the variants are expressed in brain and retina, although there are non-neuronal variants that may have different functional properties. GRM7 has been reported to be expressed in active zones of presynaptic axon terminals in various regions of the brain, eye, and spinal cord. Caution: GLUR7 refers to Ionotropic Glutamate Receptor 7, not to Metabotropic Glutamate Receptor 7 (mGLUR7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRM7
• Entrez:
  • 2917(Human)