mGluR7 [p Ser862] Antibody

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Western Blot: mGluR7 [p Ser862] Antibody [NBP1-47557] - Mouse brain lysate demonstrating specific immunolableing of the 102kDa mGluR7 [p Ser862] Immunolabeling is blocked by the phospho-peptide used as immunogen ...read more

Product Details

Summary
Reactivity Mu, Rt, Hu, Bv, Ca, Pm, ZeSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

mGluR7 [p Ser862] Antibody Summary

Immunogen
Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser862 of Rat Metabotropic Glutamate Receptor 7.
Modification
p Ser862
Specificity
Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.
Predicted Species
Human (100%), Canine (100%), Primate (100%), Bovine (100%), Zebrafish (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRM7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for mGluR7 [p Ser862] Antibody

  • FLJ40498
  • glutamate receptor, metabotropic 7
  • GPRC1G
  • GRM7
  • metabotropic glutamate receptor 7
  • MGLU7
  • mGluR7
  • MGLUR7GPRC1GGLUR7

Background

Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GRM7
Entrez
Uniprot