mGluR5 Antibody

Immunohistochemistry-Paraffin: mGluR5 Antibody [NLS889] - Analysis of anti-GRM5 / MGLUR5 antibody with human brain, neurons and glia at 2.5 ug/ml.

Product Discontinued

mGluR5 Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from C-terminus of human GRM5 / MGLUR5.
• Specificity: Human GRM5 / MGLUR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CDC42EP5 (69%).
• Predicted Species: Rabbit (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRM5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 16 ug/ml
  • Western Blot 1:1000 - 1:10000

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoset (81%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for mGluR5 Antibody

• glutamate receptor, metabotropic 5
• GPRC1E
• GPRC1EMGLUR5metabotropic glutamate receptor 5
• GRM5
• mGlu5
• mGluR5

Background

Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia. Summary of expresson: GRM5 has been reported to be expressed in various regions of the brain as well as in the spinal cord and dorsal root ganglia. ESTs have been isolated from human brain, eye, testis, and fetal libraries. Caution: GLUR5 refers to Ionotropic Glutamate Receptor 5, not to Metabotropic Glutamate Receptor 5 (mGLUR5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRM5
• Entrez:
  • 2915(Human)