mGluR5 Products

Antibodies
mGluR5 Antibody (464823)
mGluR5 Antibody (464823)
MAB45141
Species: Hu
Applications: IHC
Host: Mouse Monoclonal
mGluR5 Antibody [Unconjugated ...
mGluR5 Antibody [Unconjugated]
AF4514
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
mGluR5 Antibody (464818) [Unc ...
mGluR5 Antibody (464818) [Unconjug...
MAB4514
Species: Hu
Applications: WB, ICFlow
Host: Mouse Monoclonal
Proteins
mGluR5 Partial Recombinant Pr ...
mGluR5 Partial Recombinant Protein
H00002915-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
mGluR5 RNAi
mGluR5 RNAi
H00002915-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. It has been suggested that mGluR5 may be the primary high affinity ACPD receptor in CA1 neurons (1). Also, neuroprotection by mGluR system has been linked to the modulation of both the free radical nitric oxide (NO) and programmed cell death (PCD). Activation of group I mGluR subtypes utilized an effective, "upstream" mechanism for the inhibition of cysteine protease activity that offered an enhanced level of neuroprotection through both the preservation of genomic DNA integrity and the maintenance of PS membrane asymmetry (2). It has also been shown that activation of mGluRs enhances formation of an mGluR-Homer-PIKE-L complex, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Our findings indicate that this complex mediates the well-known ability of agonists of mGluR5 to prevent neuronal apoptosis (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 2915
Alternate Names
  • mGluR5
  • mGlu5
  • GPRC1EMGLUR5metabotropic glutamate receptor 5
  • glutamate receptor, metabotropic 5

Pathways for mGluR5

View related products by pathway and learn more about each of the pathways below.

Chemotaxis
System Development
Nervous System Development
Cell Differentiation
Synaptic Transmission
Neurogenesis
Cell Growth
Central Nervous System Development

Research Areas for mGluR5

Find related products by research area and learn more about each of the different research areas below.

GPCR
Metabotropic Glutamate Receptors
Neuronal Cell Markers
Neurotransmission

PTMs for mGluR5

Learn more about PTMs related to mGluR5.

Phosphorylation

Bioinformatics Tool for mGluR5

Discover related pathways, diseases and genes to mGluR5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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