mGluR5 Products

mGluR5 Antibody (1A11D10)
mGluR5 Antibody (1A11D10)
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
mGluR5 Antibody (464823)
mGluR5 Antibody (464823)
Species: Hu
Applications: IHC
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Recombinant Human mGluR5 Prot ...
Recombinant Human mGluR5 Protein, CF
Species: Hu
Formulation Catalog # Availability Price  


L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. It has been suggested that mGluR5 may be the primary high affinity ACPD receptor in CA1 neurons (1). Also, neuroprotection by mGluR system has been linked to the modulation of both the free radical nitric oxide (NO) and programmed cell death (PCD). Activation of group I mGluR subtypes utilized an effective, "upstream" mechanism for the inhibition of cysteine protease activity that offered an enhanced level of neuroprotection through both the preservation of genomic DNA integrity and the maintenance of PS membrane asymmetry (2). It has also been shown that activation of mGluRs enhances formation of an mGluR-Homer-PIKE-L complex, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Our findings indicate that this complex mediates the well-known ability of agonists of mGluR5 to prevent neuronal apoptosis (3).


Entrez Human
Uniprot Human
Product By Gene ID 2915
Alternate Names
  • mGluR5
  • mGlu5
  • GPRC1EMGLUR5metabotropic glutamate receptor 5
  • glutamate receptor, metabotropic 5

Pathways for mGluR5

View related products by pathway and learn more about each of the pathways below.

System Development
Nervous System Development
Cell Differentiation
Synaptic Transmission
Cell Growth
Central Nervous System Development

Research Areas for mGluR5

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Metabotropic Glutamate Receptors
Neuronal Cell Markers

PTMs for mGluR5

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Bioinformatics Tool for mGluR5

Discover related pathways, diseases and genes to mGluR5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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