mGluR2 Antibody

Immunohistochemistry-Paraffin: mGluR2 Antibody [NLS895] - Analysis of anti-GRM2 / MGLUR2 antibody with human brain, neurons and glia.

Product Discontinued

mGluR2 Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM2 / MGLUR2.
• Epitope: N-terminal extracellular domain of human
• Specificity: Human mGluR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Chimpanzee (100%), Bovine (94%), Canine (94%), Bat (94%), Equine (94%), Primate (94%), Monkey (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRM2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 19 ug/ml
  • Western Blot 1:1000 - 1:10000

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Mouse (88%), Rat (88%), Turkey (82%), Chicken (82%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for mGluR2 Antibody

• GLUR2
• glutamate metabotropic receptor 2
• glutamate receptor, metabotropic 2
• GPRC1B
• GPRC1Bmetabotropic glutamate receptor 2
• GRM2
• mGlu2
• mGluR2
• MGLUR2glutamate receptor homolog
• mGluR7

Background

The Metabotropic Glutamate Receptor GRM2 binds L-glutamate and has been linked to the inhibition of the cyclic AMP signaling cascade. GRM2 is involved in mediating the suppression of neurotransmission and in synaptogenesis and synaptic stabilization. Glutamatergic neurotransmission plays a role in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. GRM2 has been reported in various regions of the human and animal brain, as well as in rat eye and spinal cord. ESTs have been isolated from brain and testis libraries. Caution: GLUR2 refers to Ionotropic Glutamate Receptor 2, not to Metabotropic Glutamate Receptor 2 (mGLUR2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRM2
• Entrez:
  • 2912(Human)