mGluR2 Antibody

Images

 
Western Blot: mGluR2 Antibody [NBP1-68855] - Analysis of metabotropic Glutamate Receptor 2 in Human Hippocampus lysate (35ug protein in RIPA buffer) using NBP1-68855 at 1ug/ml. Primary incubation was 1 hour. Detected by ...read more
Immunohistochemistry-Paraffin: mGluR2 Antibody [NBP1-68855] - Staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated

Order Details

mGluR2 Antibody Summary

Immunogen
Peptide with sequence C-KETAPERREV corresponding to internal region according to NP_001123535.1.
Epitope
C-KETAPERREV
Specificity
This antibody is expected to recognize both isoforms (NP_000830.2; NP_001123535.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GRM2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Immunohistochemistry 3 - 5 ug/ml
  • Immunohistochemistry-Paraffin 3 - 5 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Approx. 30 kDa band observed in human brain (hippocampus) lysates (calculated MW of 27.5 kDa band according to NP_001123535.1). IHC-P: Human cerebral cortex shows membranous/axonal staining.
Publications
Read Publication using NBP1-68855.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine, Rabbit.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for mGluR2 Antibody

  • GLUR2
  • glutamate metabotropic receptor 2
  • glutamate receptor, metabotropic 2
  • GPRC1B
  • GPRC1Bmetabotropic glutamate receptor 2
  • GRM2
  • mGlu2
  • mGluR2
  • MGLUR2glutamate receptor homolog
  • mGluR7

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for mGluR2 Antibody (NBP1-68855)(1)

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GRM2
Entrez
Uniprot