mGluR1 Antibody (JM11-61)

Western Blot: mGluR1 Antibody (JM11-61) [NBP2-66945] - Analysis of mGluR1 on rat brain tissue lysates using anti-mGluR1 antibody at 1/500 dilution.

Immunohistochemistry-Paraffin: mGluR1 Antibody (JM11-61) [NBP2-66945] - Analysis of paraffin-embedded mouse kidney tissue using anti-mGluR1 antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: mGluR1 Antibody (JM11-61) [NBP2-66945] - Analysis of paraffin-embedded mouse brain tissue using anti-mGluR1 antibody. Counter stained with hematoxylin.

Product Discontinued

mGluR1 Antibody (JM11-61) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Recombinant protein within Human mGluR1 aa 280-420 / 1194. (SwissProt: Q13255 Human; SwissProt: P97772 Mouse; SwissProt: P23385 Rat)
• Localization: Cell membrane.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: GRM1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for mGluR1 Antibody (JM11-61)

• glutamate receptor, metabotropic 1
• GPRC1A
• GRM1
• GRM1A
• metabotropic glutamate receptor 1
• mGluR1
• MGLUR1A
• MGLUR1GPRC1AmGlu1

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. The Glutamate Receptor, Metabotropic, 1, (mGluR1 alpha) activates phospholipase C and participates in the central action of glutamate in the central nervous system, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRM1