MCT1/SLC16A1 Antibody (882616) [Phycoerythrin]

Mouse Anti-Human MCT1/SLC16A1 PE-conjugated Monoclonal Antibody (Catalog # FAB8275P) was detected in (A) HEK293 human embryonic kidney cell line transfected with human MCT1/SLC16A1 and eGFP or (B) Irrelevant transfectants. Quadrant markers were set based on control antibody staining (IC003P). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 882616
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

MCT1/SLC16A1 Antibody (882616) [Phycoerythrin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human MCT1/SLC16A1
  Met1-Val500
  Accession # P53985
• Specificity: Stains human MCT1/SLC16A1 transfected cells but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SLC16A1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MCT1/SLC16A1 Antibody (882616) [Phycoerythrin]

• FLJ36745
• HHF7
• MCT 1
• MCT
• MCT1
• MCT1MGC44475
• member 1
• monocarboxylate transporter 1
• SLC16A1
• Solute carrier family 16 member 1
• solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Background

Solute Carrier, family 16, member 1 (SLC16A1) encodes Monocarboxylic Acid Transporter 1 (MCT1).  MCT1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. MCT1 has been found to be important in lactate uptake in cancer cells, and blockade of MCT1 may inhibit lactate-induced HIF-1 activation (1).

1. Sonveaux, P. et al (2012) PLoS ONE 7:e33418.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC16A1
• Uniprot:
  • P53985()