MCT1/SLC16A1 Antibody (882616) [Alexa Fluor™ Plus 555]

• Clone: 882616
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

MCT1/SLC16A1 Antibody (882616) [Alexa Fluor™ Plus 555] Summary

• Specificity: Stains human MCT1/SLC16A1 transfected cells but not irrelevant transfectants in flow cytometry.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Solute Carrier, family 16, member 1 (SLC16A1) encodes Monocarboxylic Acid Transporter 1 (MCT1).  MCT1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. MCT1 has been found to be important in lactate uptake in cancer cells, and blockade of MCT1 may inhibit lactate-induced HIF-1 activation (1).

1. Sonveaux, P. et al (2012) PLoS ONE 7:e33418.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.