MAL Antibody

Product Discontinued

MAL Antibody Summary

• Immunogen: Peptide with sequence C-QDGFTYRHYHEN corresponding to internal region according to NP_071884.1.
• Epitope: C-QDGFTYRHYHEN
• Specificity: This antibody is expected to recognise isoform a (NP_002362.1) and isoform c (NP_071884.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MAL
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:4000
• Application Notes: WB: Preliminary experiments gave an approx. 35 kDa band in human thymus and thyroid gland lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 16.7 kDa band according to NP_002362.1. The 35 kDa band was successfully blocked by incubation with the immunizing peptide.
• Control:

  MAL Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for MAL Antibody

• mal, T-cell differentiation protein
• myelin and lymphocyte protein
• T-cell differentiation protein MAL
• T-lymphocyte maturation-associated protein

Background

The protein encoded by the MAL gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MAL Antibody (NBP1-06086)(1)

Publication using NBP1-06086

• Khor CC, Chapman SJ, Vannberg FO et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet 2007-04-01 [PMID: 17322885]

Bioinformatics

• Gene Symbol: MAL
• Entrez:
  • 4118(Human)
  • 17153(Mouse)
  • 25263(Rat)
• Uniprot:
  • P21145(Human)