Recombinant Mouse M-CSF Protein

Images

 
Functional: Recombinant Mouse M-CSF Protein [NBP1-43151] - Proliferation of M-NFS-60 cells in response to Mouse M-CSF Recombinant Protein.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Func
Concentration
0.1 mg/ml

Order Details

Recombinant Mouse M-CSF Protein Summary

Description
Insect expressed C-terminal His-tagged Lys33-Pro187, Accession #: NM_001113530.

Source: Insect

Details of Functionality
The ED50 of this protein, as determined by M-NFS-60 proliferation, is less than or equal to 10 ng/ml. This corresponds to a specific activity of greater than or equal to 1 x 10^5Units/mg.
Protein/Peptide Type
Biologically Active Protein
Gene
CSF1
Purity
>95% pure by SDS-PAGE
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Theoretical MW
37.79 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid; phosphate buffered saline with 1% BSA, pH 7.2
Preservative
0.09% Sodium Azide
Concentration
0.1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Mouse M-CSF Protein

  • colony stimulating factor 1 (macrophage)
  • CSF1
  • CSF-1
  • Lanimostim
  • macrophage colony stimulating factor
  • macrophage colony-stimulating factor 1
  • MCSF
  • M-CSF
  • MCSFlanimostim
  • MGC31930

Background

Macrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-37292
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP2-42388
Species: Hu
Applications: WB, IHC, IHC-P
NB100-56505
Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready
NB100-56508
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IHC-P, CyTOF-ready, Flow-CS

Publications for M-CSF Biologically Active Protein (NBP1-43151) (0)

There are no publications for M-CSF Biologically Active Protein (NBP1-43151).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for M-CSF Biologically Active Protein (NBP1-43151) (0)

There are no reviews for M-CSF Biologically Active Protein (NBP1-43151). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for M-CSF Biologically Active Protein (NBP1-43151) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional M-CSF Products

Bioinformatics Tool for M-CSF Biologically Active Protein (NBP1-43151)

Discover related pathways, diseases and genes to M-CSF Biologically Active Protein (NBP1-43151). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for M-CSF Biologically Active Protein (NBP1-43151)

Discover more about diseases related to M-CSF Biologically Active Protein (NBP1-43151).
 

Pathways for M-CSF Biologically Active Protein (NBP1-43151)

View related products by pathway.

PTMs for M-CSF Biologically Active Protein (NBP1-43151)

Learn more about PTMs related to M-CSF Biologically Active Protein (NBP1-43151).
 

Research Areas for M-CSF Biologically Active Protein (NBP1-43151)

Find related products by research area.

Blogs on M-CSF

There are no specific blogs for M-CSF, but you can read our latest blog posts.

Customers Who Bought This Also Bought

M-CSF
416-ML-010/CF

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Mouse M-CSF Protein and receive a gift card or discount.

Bioinformatics

Gene Symbol CSF1
Entrez