Recombinant Mouse M-CSF Protein Summary
Insect expressed C-terminal His-tagged Lys33-Pro187, Accession #: NM_001113530.
|Details of Functionality
The ED50 of this protein, as determined by M-NFS-60 proliferation, is less than or equal to 10 ng/ml. This corresponds to a specific activity of greater than or equal to 1 x 10^5Units/mg.
| Protein/Peptide Type
>95% pure by SDS-PAGE
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
PBS (pH 7.2) with 1% BSA
>95% pure by SDS-PAGE
Alternate Names for Recombinant Mouse M-CSF Protein
- colony stimulating factor 1 (macrophage)
- macrophage colony stimulating factor
- macrophage colony-stimulating factor 1
Macrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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