M-CSF Antibody Summary
Recombinant full length mouse protein M-CSF, expressed in E.Coli.
Shows approximately 5% cross-reactivity with recombinant human M-CSF.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Immunogen affinity purified
ELISA: Detect a limit of ~0.16 ng/well of recombinant mouse MCSF. Neut: Use at a concentration of 0.015 - 0.035 ug/ml to neutralize 50% of the bioactivity due to 2.5 ng/ml recombinant mouse MCSF using M-NFS-60 cells. WB: detect mouse M-CSF at 5 ng/lane under non-reducing and reducing conditions. Predicted molecular weight: 60 kDa.
Cross-reacts with Mouse.Not yet tested in other species.
Alternate Names for M-CSF Antibody
- colony stimulating factor 1 (macrophage)
- macrophage colony stimulating factor
- macrophage colony-stimulating factor 1
Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors.Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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