LYVE-1 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

LYVE-1 Antibody [DyLight 405] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human LYVE1 protein sequence (between residues 250-322). [UniProt# Q9Y5Y7]
Localization
Plasma membrane
Marker
Lymphatic Vessel Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LYVE1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
This LYVE1 antibody is useful for Western blot, where a band is observed at ~45 kDa. This antibody has been tested on human recombinant LYVE-1 and mouse spleen lysate. For Immunohistochemistry we recommend NB100-725.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LYVE-1 Antibody [DyLight 405]

  • cell surface retention sequence binding protein-1
  • Cell surface retention sequence-binding protein 1
  • CRSBP1
  • CRSBP-1
  • extracellular link domain containing 1
  • extracellular link domain-containing 1
  • Extracellular link domain-containing protein 1
  • HAR
  • Hyaluronic acid receptor
  • lymphatic vessel endothelial hyaluronan receptor 1
  • lymphatic vessel endothelial hyaluronic acid receptor 1
  • LYVE1
  • LYVE-1
  • LYVE-1XLKD1
  • XLKD1

Background

LYVE1 (lymphatic vessel endothelial hyaluronan receptor-1) is the lymphatic vessel endothelial hyaluronic acid receptor located in lymph nodes and in the luminal/abluminal surfaces of lymphatic vessels. It is one of the most specific and widely used mammalian lymphatic endothelial markers. LYVE-1 exists as disulfide-linked homodimer, can interact with PDGFB/IGFBP3 and also forms transient ternary complex with PDGFB and PDGFRB in trans-Golgi network (TGN). LYVE1 is a single-pass type I membrane protein localized in plasma membrane and in vesicles near extranuclear membranes which represents TGN and endosomes or pre-lysosomeal compartments. LYVE1 undergoes ligand-dependent internalization and recycling at the cell surface, and executes ligand-specific transporter trafficking between intracellular organelles/TGN and plasma membrane. LYVE1 plays a key role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding. LYVE1 behaves as hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. LYVE-1 is very efficient in the passage of lymphocytes as well as the tumor cells into the lymphatics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol LYVE1
Entrez