Ly-6G6C Antibody (NIMP-R14) [FITC]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow, IA, IHC, IHC-Fr, IHC-P
Clone
NIMP-R14
Clonality
Monoclonal
Host
Rat
Conjugate
FITC
Concentration
0.1 mg/ml

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Catalog# & Conjugate Size Price

Ly-6G6C Antibody (NIMP-R14) [FITC] Summary

Immunogen
Purified BALB/c mouse neutrophils
Epitope
This antibody recognizes a currently undetermined structure on the Neutrophil membrane
Specificity
mouse Ly-6G6C
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
LY6G6C
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Publications
Read Publications using NBP1-60139.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 26831939).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
1 ml (100 ug/ml) 0.2 um filtered FITC conjugated antibody solution in PBS and 1.0% BSA
Preservative
0.05% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for Ly-6G6C Antibody (NIMP-R14) [FITC]

  • C6orf24
  • G6c
  • lymphocyte antigen 6 complex locus protein G6c
  • lymphocyte antigen 6 complex, locus G6C
  • NG24
  • UNQ1947/PRO4430

Background

Ly6G is a GPI-anchored protein, that is also known as the myeloid differentiation antigen Gr1. The antigen is transiently expressed on monocytes in the bone marrow. The level of antigen expression in the bone marrow directly correlates with granulocyte differentiation and maturation. Ly6G is expressed predominantly on neutrophils, also in a subset of eosinophils, differentiating pre-monocytes, and plasmacytoid dendritic cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Ly-6G6C Antibody (NBP1-60139)(8)


Showing Publications 1 - 8 of 8.
Publications using NBP1-60139 Applications Species
Navarini AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V, Odermatt B, Hengartner H, Zinkernagel RM. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. Proc Natl Acad Sci U S A;106(17):7107-12. 2009 Apr 28. [PMID: 19351895]
Nagendra S, Schlueter AJ. Absence of cross-reactivity between murine Ly-6C and Ly-6G. Cytometry A;58(2):195-200. 2004 Apr. [PMID: 15057973]
de Vries B, Kohl J, Leclercq WK, Wolfs TG, van Bijnen AA, Heeringa P, Buurman WA. Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils. J Immunol;170(7):3883-9. 2003 Apr 1. [PMID: 12646657]
Tacchini-Cottier F, Zweifel C, Belkaid Y, Mukankundiye C, Vasei M, Launois P, Milon G, Louis JA. An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major. J Immunol. 165(5):2628-36. 2000 Sep 1. [PMID: 10946291]
Lubberts E, Joosten LA, van Den Bersselaar L, Helsen MM, Bakker AC, van Meurs JB, Graham FL, Richards CD, van Den Berg WB. Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J Immunol;163(8):4546-56. 1999 Oct 15. [PMID: 10510398]
Van Lent PL, Blom A, Holthuysen AE, Jacobs CW, Van De Putte LB, Van Den Berg WB. Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice. J Leukoc Biol;61(3):267-78. 1997 Mar. [PMID: 9060449]
Lopez AF, Strath M, Sanderson CJ. Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies. Br J Haematol;57(3):489-94. 1984 Jul. [PMID: 6743568]
McLaren DJ, Strath M, Smithers SR. Schistosoma mansoni: evidence that immunity in vaccinated and chronically infected CBA/Ca mice is sensitive to treatment with a monoclonal antibody that depletes cutaneous effector cells. Parasite Immunol;9(6):667-82. 1987 Nov. [PMID: 3124065]

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Ly-6G6C NBP1-60139

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Bioinformatics

Gene Symbol LY6G6C