LST1 Antibody (LST1/02) [CoraFluor™ 1]

• Reactivity: Hu
• Applications: WB, ICC/IF, IP
• Clone: LST1/02
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: CoraFluor 1

LST1 Antibody (LST1/02) [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
• Immunogen: KLH-fused peptide corresponding to amino acids SSEGPDLRGRDKRGT of human LST1
• Specificity: The antibody LST1/02 reacts with an extracellular epitope of LST1, an approximately 6-11 kDa protein expressed as various transmembrane or soluble forms. LST1 is found predominantly on monocytes and dendritic cells. It migrates on SDS PAGE gels as approximately 25-28 kDa molecule.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: LST1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for LST1 Antibody (LST1/02) [CoraFluor™ 1]

• B144D6S49ELST-1
• leucocyte specific transcript 1
• leukocyte specific transcript 1
• leukocyte-specific transcript 1 protein
• lymphocyte antigen 117
• MGC119006
• MGC119007
• Protein B144

Background

LST1, also known as Leukocyte-specific transcript 1 protein, has 10 isoforms ranging from a 13 amino acid isoform that is 1 kDa to a 97 amino acid isoform that is 11 kDa, can inhibit the proliferation of lymphocytes, induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may participate in dendritic cell maturation. Disease research is currently being performed with relation to LST1 and vulvovaginitis, rhinotracheitis, chronic venous leg ulcers, proliferative vitreoretinopathy, systemic lupus erythematosus, vitreoretinopathy, rubella, lupus erythematosus, tonsillitis, diabetes mellitus, lung cancer, and Graves' disease. Interactions with this protein have been shown to involve G2E3, PRKCB and CACTIN in cell morphogenesis, immune response, regulation of cell shape, anatomical structure morphogenesis, and dendrite development pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LST1