LRRK2 Antibody


Genetic Strategies: Knockout Validated: LRRK2 Antibody [NB110-58771] - Western blot shows lysates of HeLa human cervical epithelial carcinoma parental cell line and LRRK2 knockout (KO) HeLa cell line. PVDF more
Western Blot: LRRK2 Antibody [NB110-58771] - NB110-58771 in increasing amounts of human lymphoblast
Immunocytochemistry/ Immunofluorescence: LRRK2 Antibody [NB110-58771] - Immunofluorescence of Lrrk2 with NB110-58771 within (A) Substantia nigra neurons (B) Chains of migrating neuroblasts.
Immunohistochemistry-Frozen: LRRK2 Antibody [NB110-58771] - DAB Immunostaining in frozen sections of mouse brainstem.

Product Details

Reactivity Hu, Mu, Rt, Pm, PoSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP, KO
1 mg/ml
Validated by:

Genetic Strategies


LRRK2 Antibody Summary

A synthetic peptide made to a C-terminal region, within residues 2500-2527 of the human LRRK2 protein, conjugated to KLH. [Swiss-Prot# Q5S007]
Cytoplasm. Membrane; Peripheral membrane protein.
Predicted Species
Porcine (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:500-1:1000
  • Immunohistochemistry 1:200-1:500
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation 1:10-1:500
  • Knockout Validated
Application Notes
This LRRK2 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot blot analysis, where a band is seen ~286 kDa. Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 24312256)
Theoretical MW
286 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
LRRK2 Lysate (NBP2-66407)
Read Publications using
NB110-58771 in the following applications:

Reactivity Notes

Human, rat, mouse and primate. Predicted to react with porcine based on 100% sequence homology.

Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
0.05% Sodium Azide
1 mg/ml
Immunogen affinity purified

Alternate Names for LRRK2 Antibody

  • augmented in rheumatoid arthritis 17
  • AURA17
  • Dardarin
  • DKFZp434H2111
  • EC
  • FLJ45829
  • leucine-rich repeat kinase 2
  • leucine-rich repeat serine/threonine-protein kinase 2
  • LRRK2
  • PARK8
  • Parkinson disease (autosomal dominant) 8
  • RIPK7
  • ROCO2


LRRK2 (leucine-rich repeat serine/threonine-protein kinase 2, also called PARK8 or Dardarin) is a homodimeric multifunctional protein that belongs to TKL serine threonine protein kinases family and LRRK2 immunoreactivity has been documented in neurofibrillary tangles in Alzheimer's disease as well as in PDCG (parkinsonism-dementia complex of Guam). Highly expressed in tissues such as liver, heart, brain etc., LRRK2 localizes to cellular cytoplasm and also associates with membrane structures including mitochondrial outer membrane. LRRK interacts with PARK2, PRDX3 and TPCN2, and phosphorylate proteins which are implicated in Parkinson disease. LRRK2 is a cytoplasmic kinase with autophosphorylation capability as well as GTPase activity. Its interaction with microtubules suggests that LRRK2-induced neurodegeneration might be partly mediated via inhibition of microtubule dynamics, and LRRK2 -mitochondria interactiosn suggests its implication in pathways eliciting ROS mediated damage. LRRK2 has been shown exert positive regulation in autophagy via calcium-sensitive activation of CaMKK/AMPK signaling pathway through activation of NAADP receptors, increase of lysosomal pH as well as calcium release.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LRRK2 Antibody (NB110-58771)(7)

We have publications tested in 3 confirmed species: Human, Mouse, Primate.

We have publications tested in 4 applications: ICC/IF, IHC, IHC-P, WB.

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Product General Protocols

View specific protocols for LRRK2 Antibody (NB110-58771): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for LRRK2 Antibody (NB110-58771). (Showing 1 - 1 of 1 FAQs).

  1. Is the immunogen of NB110-58771 within amino acids 922 and 1143 of LRRK2 (Uniprot ID#Q5S007)?
    • The immunogen used to generate NB110-58771 was a synthetic peptide made to a C-terminal region within residues 2500-2527 of the human LRRK2 protein (UniProt # Q5S007). We do have an alternative antibody that you may be interested in, with catalog number NB110-55289. The immunogen used to generate this product was synthetic peptide made to an internal region of the mouse LRRK2 protein sequence (between residues 900-1000), although this does not recognize human LRRK2. If you are looking to detect mouse LRRK2 this would be a suitable product for you.

Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-58771AF405
Alexa Fluor 488 Labeled NB110-58771AF488
Alexa Fluor 647 Labeled NB110-58771AF647
Alexa Fluor 700 Labeled NB110-58771AF700
Biotin Labeled NB110-58771B
DyLight 405 Labeled NB110-58771V
DyLight 488 Labeled NB110-58771G
DyLight 550 Labeled NB110-58771R
DyLight 650 Labeled NB110-58771C
FITC Labeled NB110-58771F
HRP Labeled NB110-58771H

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Research Areas for LRRK2 Antibody (NB110-58771)

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Blogs on LRRK2.

The role of Parkin and autophagy in retinal pigment epithelial cell (RPE) degradation
The root of Parkinson’s disease (PD) points to a poorly regulated electron transport chain leading to mitochondrial damage, where many proteins need to work cohesively to ensure proper function.  The two key players of this pathway are PINK1,...  Read full blog post.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

Parkinson's Disease Infographic
Parkinson's disease affects the nervous system which controls movement. Damage to the levels of dopamine in the brain impairs the ability to relay messages to parts of the body which control movement. While the exact cause of the disease is unknown, r...  Read full blog post.

Novus Antibodies Highlighted in Parkinson's Disease Research
Identified almost two centuries ago, Parkinson's disease is a neurodegenerative disorder that afflicts an estimated 4-6 million worldwide ( The prevalence of Parkinson's disease is expected to grow considerably as the average age o...  Read full blog post.

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Gene Symbol LRRK2