Western Blot: ATP13A2 Antibody [NB110-41486] - Detection of ATP13A2 in mouse brain membrane lysate.
Immunohistochemistry: ATP13A2 Antibody [NB110-41486] - Staining of neurons and neuropils using a concentration of 10ug/ml. Human brain, 40X.
Simple Western: ATP13A2 Antibody [NB110-41486] - Simple Western lane view shows a specific band for ATP13A2 in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 ...read more
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinsons disease.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for ATP13A2 Antibody (NB110-41486). (Showing 1 - 2 of 2 FAQs).
Would you be able to share the protocol used to produce the WB image for NB110-41486 - ATP13A2 antibody?
Please find the specific protocol used for NB110-41486 in Western Blot from this link: Western Blot Protocol
Would you be able to share whether or not NB110-41486 is expected to react with rat ATP13A2 (http://www.uniprot.org/uniprot/?query=atp13a2&fil=organism%3A%22Rattus+norvegicus+%28Rat%29+%22&sort=score (http://www.uniprot.org/uniprot/?query=atp13a2&f
According to the information I have available, it looks like there is an 89% homology between the region where the immunogen lies of the human sequence and the corresponding region of the rat sequence. However, the rat sequence is uncharacterized, so we cannot guarantee the accuracy of the homology. It looks like this is promising; however, we have not yet tested this antibody in rat and cannot guarantee its performance.