LRRK2 Antibody


Western Blot: LRRK2 Antibody [NB110-55289] - Detection of murine LRRK2 in mouse brain lysate.
Immunohistochemistry: LRRK2 Antibody [NB110-55289] - Staining of neurons and glia. Mouse Brain, 40X.

Product Details

Reactivity Mu, Hu(-)Species Glossary
Applications WB, IHC, IHC-P
1.09 mg/ml

LRRK2 Antibody Summary

A synthetic peptide made to an internal region of the mouse LRRK2 protein sequence (between residues 900-1000). [Swiss-Prot# Q5S006]
Mitochondrial outer membrane
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-citrate/phosphate, pH 7-8
0.1% Sodium Azide
1.09 mg/ml
Immunogen affinity purified


Application Notes
This LRRK2 antibody is useful inThis antibody is useful for Immunohistochemistry paraffin embedded sections and Western blot analysis, where a band is seen at ~284 kDa. There is a band at ~171 and 117 kDa, as well as several lower molecular weight, non-specific bands.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
285 kDa
Control Peptide
LRRK2 Peptide (NB110-55289PEP)

Reactivity Notes

Mouse. Does not react with Human.

Alternate Names for LRRK2 Antibody

  • augmented in rheumatoid arthritis 17
  • AURA17
  • Dardarin
  • DKFZp434H2111
  • EC
  • FLJ45829
  • leucine-rich repeat kinase 2
  • leucine-rich repeat serine/threonine-protein kinase 2
  • PARK8
  • Parkinson disease (autosomal dominant) 8
  • RIPK7
  • ROCO2


LRRK2 (leucine-rich repeat serine/threonine-protein kinase 2, also called PARK8 or Dardarin) is a homodimeric multifunctional protein that belongs to TKL serine threonine protein kinases family and LRRK2 immunoreactivity has been documented in neurofibrillary tangles in Alzheimer's disease as well as in PDCG (parkinsonism-dementia complex of Guam). Highly expressed in tissues such as liver, heart, brain etc., LRRK2 localizes to cellular cytoplasm and also associates with membrane structures including mitochondrial outer membrane. LRRK interacts with PARK2, PRDX3 and TPCN2, and phosphorylate proteins which are implicated in Parkinson disease. LRRK2 is a cytoplasmic kinase with autophosphorylation capability as well as GTPase activity. Its interaction with microtubules suggests that LRRK2-induced neurodegeneration might be partly mediated via inhibition of microtubule dynamics, and LRRK2 -mitochondria interactiosn suggests its implication in pathways eliciting ROS mediated damage. LRRK2 has been shown exert positive regulation in autophagy via calcium-sensitive activation of CaMKK/AMPK signaling pathway through activation of NAADP receptors, increase of lysosomal pH as well as calcium release.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for LRRK2 Antibody (NB110-55289): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-55289AF405
Alexa Fluor (R) 488 Labeled NB110-55289AF488
Alexa Fluor (R) 647 Labeled NB110-55289AF647
Alexa Fluor (R) 700 Labeled NB110-55289AF700
Biotin Labeled NB110-55289B
DyLight 405 Labeled NB110-55289V
DyLight 488 Labeled NB110-55289G
DyLight 550 Labeled NB110-55289R
DyLight 650 Labeled NB110-55289C
FITC Labeled NB110-55289F
HRP Labeled NB110-55289H

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Blogs on LRRK2.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

Parkinson's Disease Infographic
Parkinson's disease affects the nervous system which controls movement. Damage to the levels of dopamine in the brain impairs the ability to relay messages to parts of the body which control movement. While the exact cause of the disease is unknown, r...  Read full blog post.

Novus Antibodies Highlighted in Parkinson's Disease Research
Identified almost two centuries ago, Parkinson's disease is a neurodegenerative disorder that afflicts an estimated 4-6 million worldwide ( The prevalence of Parkinson's disease is expected to grow considerably as the average age o...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol LRRK2

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