LNK/SH2B3 Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: LNK/SH2B3 Antibody [NBP1-87867] - Staining of human cell line U-2 OS shows localization to nucleoplasm. Antibody staining is shown in green.

Analysis in human cell line HEL.

• Reactivity: Hu, Rt
• Applications: WB, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

LNK/SH2B3 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit LNK/SH2B3 Antibody - BSA Free (NBP1-87867) is a polyclonal antibody validated for use in IHC, WB and ICC/IF. Anti-LNK/SH2B3 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: FDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFH
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SH2B3
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry-Paraffin Reported in scientific literature (PMID: 25172839)
  • Western Blot 0.04-0.4 ug/ml
• Application Notes: ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  LNK/SH2B3 Protein (NBP1-87867PEP)

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 25172839).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for LNK/SH2B3 Antibody - BSA Free

• IDDM20
• LNK
• LNKSH2B adapter protein 3
• Lymphocyte adapter protein
• Lymphocyte-specific adapter protein Lnk
• SH2B adaptor protein 3
• SH2B3
• Signal transduction protein Lnk

Background

T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)). Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LNK/SH2B3 Antibody (NBP1-87867)(1)

Publication using NBP1-87867

• Flister MJ, Endres BT, Rudemiller N et al. CXM- a new tool for mapping breast cancer risk in the tumor microenvironment. Cancer Res 2014-11-15 [PMID: 25172839] (IF/IHC, Rat)

Bioinformatics

• Gene Symbol: SH2B3