LDLR Antibody

Product Discontinued

LDLR Antibody Summary

• Immunogen: Human Cu2+ oxidised LDL.
• Localization: Secreted (probable)
• Specificity: This antibody shows strong reactivity to fully oxidized modifications of LDL including Cu²⁺ oxidized LDL, LDL(MDA), LDL(HOCL), but not to other oxidized proteins like HSA(MDA), HDL(MDA), HSA(HOCL), HDL(HOCL). The reaction to native LDL is weak, but detectable.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LDLR
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: ELISA: Use at a dilution of 1/500 - 1/5000. IHC: Use at a dilution of <1/500. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Please contact technical support for detailed reconstituion instruction.

Alternate Names for LDLR Antibody

• FH
• FHC
• LDL R
• LDL receptor
• LDLCQ2
• LDLR
• low density lipoprotein receptor
• low-density lipoprotein receptor class A domain-containing protein 3
• low-density lipoprotein receptor

Background

When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. Oxidized lipoproteins are formed by free radical damage to lipids that accumulate in macrophages and smooth muscle cells causing foam cell formation, an initial step in the disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LDLR