KLRG1 Antibody (2F1) [Biotin]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow, IP
Clone
2F1
Clonality
Monoclonal
Host
Golden Syrian Hamster
Conjugate
Biotin

KLRG1 Antibody (2F1) [Biotin] Summary

Immunogen
IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice
Specificity
KLRG1 (Mr 30-38 kDa)
Isotype
IgG2
Clonality
Monoclonal
Host
Golden Syrian Hamster
Gene
KLRG1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1 ug/10^6 cells
  • Immunoprecipitation 1:10-1:500
Readout System

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Protect conjugated forms from light.

Alternate Names for KLRG1 Antibody (2F1) [Biotin]

  • 2F1
  • CLEC15A
  • CLEC15AMAFA-LIKE
  • C-type lectin domain family 15 member A
  • C-type lectin domain family 15, member A
  • ITIM-containing receptor MAFA-L
  • killer cell lectin-like receptor subfamily G member 1
  • killer cell lectin-like receptor subfamily G, member 1
  • KLRG1
  • MAFA
  • MAFAL
  • MAFA-L
  • MAFA-like receptor
  • MAFAMAFA-2F1
  • mast cell function-associated antigen (ITIM-containing)
  • Mast cell function-associated antigen
  • MGC13600

Background

The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1-Ag), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. (1, 2) These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. (3, 4) The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). (1, 5) Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors. (1)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP1-28115APC
DyLight 350 Labeled NBP1-28115UV
DyLight 405 Labeled NBP1-28115V
DyLight 488 Labeled NBP1-28115G
DyLight 680 Labeled NBP1-28115FR
DyLight 755 Labeled NBP1-28115IR
FITC Labeled NBP1-28116
PE Labeled NBP1-28115PE
PerCP Labeled NBP1-28115PCP

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Bioinformatics

Gene Symbol KLRG1
Entrez